Can Exercise Counteract Cancer Cachexia? A Systematic Literature Review and Meta-Analysis.
Can Exercise Counteract Cancer Cachexia? A Systematic Literature Review and Meta-Analysis.
复制标题
DOI：
10.1177/1534735420940414
复制
发表时间：
2020-01
影响因子：
2.9
通讯作者：
Schumann M
中科院分区：
文献类型：
--
作者：
Niels T;Tomanek A;Freitag N;Schumann M
癌症-恶病质与慢性炎症、肌肉代谢受损和体重下降有关，这些都是体育锻炼的经典目标。本系统综述和荟萃分析旨在确定运动对恶病质癌宿主身体和肌肉质量的影响。PubMed/Medline、EMBASE、CINHAL、ISI Web of Science和Cochrane Library被检索到2019年7月。试验必须是随机对照试验或包括癌症患者或患有恶病质诱导肿瘤的动物模型的对照试验。仅包括在受控环境中进行的至少7天的单独运动干预。评估偏倚风险，并采用随机效应模型通过标准化平均差异（SMD）汇集效应大小。所有符合条件的20项研究均在啮齿动物中进行。研究规定有氧训练（n = 15）、力量训练（n = 3）或联合训练（n = 2）。运动组与对照组腓肠肌、比目鱼肌、胫骨肌的体重和肌肉质量比较，差异无统计学意义（SMD = -0.05, 95%CI-0.64-0.55, P = 0.87）。肿瘤接种前的运动时间是肿瘤存在时体重变化的统计学调节因子（P = 0.04）。没有发现人体试验。存在很大的研究异质性，可能是由于不同的运动方式和结果报告。运动似乎不会影响啮齿类动物的癌症恶病质。然而，线性回归显示，肿瘤接种前的运动时间导致恶病质严重程度降低，可能加强了在有恶病质风险的癌症患者中使用运动的理由。
Cancer-cachexia is associated with chronic inflammation, impaired muscle metabolism and body mass loss, all of which are classical targets of physical exercise. This systematic review and meta-analysis aimed to determine the effects of exercise on body and muscle mass in cachectic cancer hosts. PubMed/Medline, EMBASE, CINHAL, ISI Web of Science, and Cochrane Library were searched until July 2019. Trials had to be randomized controlled trials or controlled trials including cancer patients or animal models with cachexia-inducing tumors. Only sole exercise interventions over at least 7 days performed in a controlled environment were included. Risk of bias was assessed and a random-effects model was used to pool effect sizes by standardized mean differences (SMD). All eligible 20 studies were performed in rodents. Studies prescribed aerobic (n = 15), strength (n = 3) or combined training (n = 2). No statistical differences were observed for body mass and muscle weight of the gastrocnemius, soleus, and tibialis muscles between the exercise and control conditions (SMD = ‒0.05, 95%CI-0.64-0.55, P = 0.87). Exercise duration prior to tumor inoculation was a statistical moderator for changes in body mass under tumor presence (P = 0.04). No human trials were identified. A large study heterogeneity was present, probably due to different exercise modalities and outcome reporting. Exercise does not seem to affect cancer-cachexia in rodents. However, the linear regression revealed that exercise duration prior to tumor inoculation led to reduced cachexia-severity, possibly strengthening the rationale for the use of exercise in cancer patients at cachexia risk.
登录
查看更多内容
DOI：
10.1002/jcsm.12232
发表时间：
2017-12
期刊：
Journal of cachexia, sarcopenia and muscle
影响因子：
--
作者：
Brown JL;Rosa-Caldwell ME;Lee DE;Blackwell TA;Brown LA;Perry RA;Haynie WS;Hardee JP;Carson JA;Wiggs MP;Washington TA;Greene NP
通讯作者：
Greene NP
影响因子：
9.8
作者：
Khamoui, Andy V.;Park, Bong-Sup;Kim, Jeong-Su
通讯作者：
Kim, Jeong-Su
影响因子：
3.7
作者：
Duval, S;Tweedie, R
通讯作者：
Tweedie, R
影响因子：
5.2
作者：
Ballaro, Riccardo;Penna, Fabio;Costelli, Paola
通讯作者：
Costelli, Paola
影响因子：
2
作者：
Higgins, JPT;Thompson, SG
通讯作者：
Thompson, SG