Direct antimicrobial properties of substance P
Direct antimicrobial properties of substance P
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DOI：
10.1016/s0024-3205(02)01740-x
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发表时间：
2002-07-05
期刊：
影响因子：
6.1
通讯作者：
Lipkowski, AW
中科院分区：
文献类型：
--
作者：
Kowalska, K;Carr, DB;Lipkowski, AW
P物质（SP，Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH 2）与富含Arg/Pro的杀菌肽的结构相似性提示SP可能对入侵微生物具有直接作用。我们现在提出的证据表明，P物质具有直接的抗菌活性，对S。金黄色。P物质拮抗剂也具有这种活性，但不如P物质激动剂S有效。金黄色葡萄球菌比P物质更有效地对抗白色念珠菌。我们的数据还表明，内源性肽缓激肽和神经降压素，也发挥作用，在调节宿主防御系统的原位，具有抗菌特性，但不如P物质的效力。（C）2002出版的爱思唯尔科学公司。
The structural similarity between substance P (SP, Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2) and Arg/Pro rich bactericidal peptides suggests a possible direct effect of SP on invasive microbes. We now present evidence that substance P possesses direct antimicrobial activity, highest against S. aureus. A substance P antagonist also possesses such activity but while less potent than substance P agonist S. aureus, is more potent than substance P against C albicans. Our data also show that the endogenous peptides bradykinin and neurotensin, that also play role in modulation of the host-defense system in situ, have antimicrobial properties but are less potent than substance P. (C) 2002 Published by Elsevier Science Inc.