Murine weight loss exhibits significant genetic variation during dietary restriction.
Murine weight loss exhibits significant genetic variation during dietary restriction.
复制标题
小鼠体重减轻在饮食限制期间表现出显着的遗传变异。
DOI：
10.1152/physiolgenomics.00068.2006
复制
发表时间：
2006
影响因子：
4.6
通讯作者：
Johnson,ThomasE
中科院分区：
文献类型：
--
作者：
Rikke,BradA;Battaglia,MatthewE;Allison,DavidB;Johnson,ThomasE
我们目前的遗传分析小鼠体重减轻饮食限制（DR）的女性吃60%的自由（AL）。我们检查了81个不同品系的5个队列（22个品系测试两次），包括LXS和LSXSS重组近交系、LXS亲本品系ILS和ISS以及经典近交系129 S6、A、BALB/c、C57 BL/6、C3 H和DBA。体重减轻表现出高度显著的遗传变异，DR体重范围为AL体重的1.60 - 1.85%。绝对摄食量、粪便卡路里含量、运动活动或AL体脂的菌株差异不能解释这种变化。遗传力为40- 50%，并定位了几个临时数量性状基因座。这种变化可用于测试体重减轻是否与DR的健康益处相关，而与卡路里的减少无关。遗传变异还意味着存在与影响AL体重或体脂的基因不同的新的治疗靶点基因，用于在食物限制期间增强（或减轻）体重减轻。
We present genetic analyses of murine weight loss during dietary restriction (DR) for females eating 60% ad libitum (AL). We examined 5 cohorts across 81 different strains (22 strains tested twice) that included the LXS and LSXSS recombinant inbred strains, the LXS parental strains ILS and ISS, and the classical inbreds 129S6, A, BALB/c, C57BL/6, C3H, and DBA. Weight loss exhibited highly significant genetic variation, with DR body weights ranging from ∼60 to ∼85% of AL body weight. This variation was not explained by the strain differences in absolute food intake, feces calorie content, motor activity, or AL body fat. Heritability was 40–50%, and several provisional quantitative trait loci were mapped. This variation can be used to test whether weight loss correlates with the health benefits of DR, independently of the reduction in calories. The genetic variation also implies the existence of genes that would be novel therapeutic targets, distinct from genes affecting AL body weight or body fat, for enhancing (or mitigating) weight loss during food restriction.