Extracellular vesicles as carriers of microRNA, proteins and lipids in tumor microenvironment.
Extracellular vesicles as carriers of microRNA, proteins and lipids in tumor microenvironment.
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DOI：
10.1002/ijc.29417
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发表时间：
2016-01-01
影响因子：
6.4
通讯作者：
Pochampally R
中科院分区：
文献类型：
--
作者：
Penfornis P;Vallabhaneni KC;Whitt J;Pochampally R
近年来，有关肿瘤微环境控制的知识不断增加，并在肿瘤发生中发挥着重要作用。正常基质细胞在肿瘤发生和发展中的作用已将我们的视野带入了细胞间交流的前沿。在这篇综述中，我们重点介绍了基于细胞外小泡(EVS)交换的间质和肿瘤细胞之间的通讯机制。我们描述了几个不断增长的证据，证明电动汽车通过它们的miRNA、脂肪、蛋白质和核酸含量来传递信息。更好地了解正常癌细胞之间这种复杂的通信方法可能会导致开发个性化诊断和治疗的新方法。
In recent years, the knowledge about the control of tumor microenvironment has increased and emerged as an important player in tumorigenesis. The role of normal stromal cells in the tumor initiation and progression has brought our vision in to the forefront of cell-to-cell communication. In this review, we focus on the mechanism of communication between stromal and tumor cells, which is based on the exchange of extracellular vesicles (EVs). We describe several, evergrowing, pieces of evidence that EVs transfer messages through their miRNA, lipid, protein and nucleic acid contents. A better understanding of this sophisticated method of communication between normal cancer cells may lead to developing novel approaches for personalized diagnostics and therapeutics.