Association of cognitive activity and neurocognitive function in blacks and whites with HIV.
Association of cognitive activity and neurocognitive function in blacks and whites with HIV.
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DOI：
10.1097/qad.0000000000001316
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发表时间：
2017-01-28
期刊：
影响因子：
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通讯作者：
Barnes LL
中科院分区：
文献类型：
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作者：
Krueger KR;Adeyemi O;Leurgans S;Shah RC;Jimenez AD;Ouellet L;Landay AL;Bennett DA;Barnes LL
老年艾滋病毒感染者有认知功能受损的风险，但关于这一群体神经认知功能相关的可改变因素的信息有限。这是一项关于认知活动和神经认知功能的横断面观察性研究。我们研究了176名老年艾滋病毒感染者（70%为非洲裔美国人，76%为男性;平均年龄= 58.7（SD = 5.5）;平均教育= 13.2（SD = 2.8））的认知活动频率与当前神经认知表现之间的关系。在根据人口统计变量调整的线性回归模型中，我们发现认知活动频率越高，与整体认知、语义记忆和感知速度方面的更好认知相关。随后的模型研究了种族的作用，表明这种关联仅在黑人的整体认知，情景记忆，工作记忆和感知速度中显着（种族认知活动的相互作用估计范围= 0.38 - 0.55;所有P <0.05）。认知活动的更高频率与老年艾滋病毒感染者，特别是老年黑人的神经认知功能更好相关。需要进行纵向研究，以评估认知活动与老年艾滋病毒感染者神经认知功能变化的关系。
Older persons with HIV are at risk for impaired cognition, yet there is limited information on modifiable factors associated with neurocognitive function in this group. This is a cross-sectional observational study of cognitive activities and neurocognitive function. We examined the relation between frequency of cognitive activity and current neurocognitive performance in 176 older persons with HIV (70% African American, 76% male; mean age = 58.7 (SD = 5.5); mean education = 13.2 (SD = 2.8). In linear regression models adjusted for demographic variables, we found that higher frequency of cognitive activity was associated with better cognition in global cognition, semantic memory, and perceptual speed. Subsequent models that examined the role of race, demonstrated that the association was significant only among Blacks for global cognition, episodic memory, working memory, and perceptual speed (interaction of cognitive activity by race Estimates range = 0.38 – 0.55; all P <0.05). Greater frequency of cognitive activity is associated with better neurocognitive function in older persons with HIV, particularly older Blacks. Longitudinal studies are needed to assess the relation of cognitive activity to change in neurocognitive function in older persons with HIV.