Insulin treatment enhances expression of IGF-I in sural nerves of diabetic patients
Insulin treatment enhances expression of IGF-I in sural nerves of diabetic patients
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DOI：
10.1002/mus.1047
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发表时间：
2001-05-01
期刊：
影响因子：
3.4
通讯作者：
Schenone, A
中科院分区：
文献类型：
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作者：
Grandis, M;Nobbio, L;Schenone, A
我们研究了胰岛素样生长因子I （IGF-I）及其受体在8例糖尿病患者（分为胰岛素治疗组（IT）和非胰岛素治疗组（NIT））腓肠神经中的表达，并与5例轴突神经病变患者和4例对照组（接受活检诊断）进行了比较。与对照组相比，糖尿病患者的胰岛素样生长因子I mRNA水平没有差异。在IT患者和轴突神经病患者的腓肠神经中，IGF-I的表达高于NIT患者和诊断对照组。IGF-I受体mRNA水平的变化与配体的变化相似，胰岛素样生长因子1免疫反应性在轴突变性的神经中更高，在IT患者中比NIT糖尿病患者和诊断对照组更高。这些发现表明胰岛素治疗增加了糖尿病神经中igf - 1的表达。我们的数据不支持人类糖尿病神经病变中igf - 1绝对缺乏的假设。Schwann细胞在严重神经损伤后不能增加igf - 1的表达，如发生在轴突神经病变中，可能是糖尿病神经病变发病的一个辅助因素，(C) 2001。
We studied the expression of insulin-like growth factor I (IGF-I) and its receptor in sural nerves from 8 diabetic patients divided into insulin-treated (IT) and non-insulin-treated (NIT) groups, compared with 5 patients with axonal neuropathies and 4 control patients (undergoing biopsies for diagnostic purposes). Insulin-like growth factor I mRNA levels did not differ in diabetic cases compared with control subjects. In sural nerves from IT patients and axonal neuropathies, IGF-I expression was higher than in NIT subjects and diagnostic controls. Changes in IGF-I receptor mRNA levels paralleled those of the ligand, Insulin-like growth factor 1 immunoreactivity was higher in nerves undergoing axonal degeneration and higher in IT than NIT diabetic patients and diagnostic controls. These findings suggest that insulin treatment increases IGF-I expression in diabetic nerves. Our data do riot support the hypothesis of an absolute IGF-I deficiency in human diabetic neuropathy. A Schwann cell's incapacity to increase IGF-I expression after severe nerve damage, as happens in axonal neuropathies, may be a cofactor in the pathogenesis of diabetic neuropathy, (C) 2001 John Wiley & Sons, Inc.