Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseases
Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseases
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DOI：
10.1038/nrd3055
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发表时间：
2010-02-01
影响因子：
120.1
通讯作者：
Cao, Yihai
中科院分区：
文献类型：
--
作者：
Cao, Yihai
目前治疗肥胖和相关代谢紊乱的药物治疗选择仍然有限且无效。新的证据表明，血管生成调节剂通过调节脂肪组织脉管系统的生长和重塑来影响脂肪量的扩张和代谢。因此，通过血管生成刺激剂和抑制剂对脂肪组织新生血管形成的药理学操作可能为肥胖和相关代谢紊乱的治疗提供一种新的治疗选择。本视角讨论了在了解控制脂肪组织血管生成的分子机制以及确定潜在的新血管靶点和治疗此类疾病的方法方面的最新进展。
Current pharmacotherapeutic options for treating obesity and related metabolic disorders remain limited and ineffective. Emerging evidence shows that modulators of angiogenesis affect the expansion and metabolism of fat mass by regulating the growth and remodelling of the adipose tissue vasculature. Pharmacological manipulation of adipose tissue neovascularization by angiogenic stimulators and inhibitors might therefore offer a novel therapeutic option for the treatment of obesity and related metabolic disorders. This Perspective discusses recent progress in understanding the molecular mechanisms that control adipose tissue angiogenesis and in defining potential new vascular targets and approaches for the treatment of this group of diseases.