A physiologically active polysaccharide hydrogel promotes wound healing
A physiologically active polysaccharide hydrogel promotes wound healing
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生理活性多糖水凝胶促进伤口愈合
DOI：
10.1002/jbm.a.32711
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发表时间：
2010-07-01
影响因子：
4.9
通讯作者：
Zhang, Junfeng
中科院分区：
文献类型：
--
作者：
Luo, Yi;Diao, Huajia;Zhang, Junfeng
当皮肤受伤时，皮下组织和器官受到病原体和过量水分流失的威胁。因此，需要伤口敷料来保护伤口部位免受感染并改善伤口愈合。天然多糖具有生物相容性好、低毒性和生物医学活性等优点，已广泛应用于创面敷料等多种生物材料中。本研究采用氧化和交联法制备了天然白芨多糖（Bletilla striata多糖，BSP）水凝胶。该BSP水凝胶具有良好的溶胀能力和适宜的水蒸气透过率。采用全层创伤小鼠模型，将水凝胶应用于活体皮肤创面愈合。与对照组相比，BSP水凝胶的愈合效果明显优于对照组。BSP组浸润炎性细胞数量和肿瘤坏死因子α (tnf - α)水平均减弱，而表皮生长因子（EGF）的分泌则显著升高。术后第11天，BSP水凝胶组创面面积仅为对照组的1/5 ~ 1/3。该新型BSP水凝胶具有控制炎症反应和加速伤口愈合的作用，在伤口愈合方面具有潜在的应用前景。(c) 2010 Wiley期刊公司[J] .中国生物医学工程学报，2016,33 (4):559 - 564
When the skin is injured, the subcutaneous tissues and organs are threatened by pathogens and excessive water loss. Wound dressings are, therefore, needed to protect the wound site from infection and improve the wound closure. Natural polysaccharides have been applied for various biomaterials including wound dressings, which show their advantages in biocompatibility, low toxicity, and pharmaceutical biomedical activity. In this study, a natural polysaccharide Bletilla striata polysaccharide (BSP) hydrogel is prepared by an oxidation and crosslinking methods. This BSP hydrogel represents preferable swelling ability and appropriate water vapor transmission rate. Using a full-thickness trauma mouse model, the hydrogel is applied on the in vim cutaneous wound healing. Compared with the control groups, the BSP hydrogel achieves the much better healing results. The quantification of the infiltrating inflammatory cells and the level of tumor necrosis factor alpha (TNF-alpha) in the BSP group are attenuated, whereas the secretion of the epidermal growth factor (EGF) is highly elevated. On the 11th day after surgery, the wound area in the BSP hydrogel group is only 1/5-1/3 of those in the control groups. This new BSP hydrogel is proved to control the inflammatory responses and accelerate the wound closure and has potential application in wound healing. (c) 2010 Wiley Periodicals, Inc. J Biomed Mater Res 94A: 193-204, 2010