Clinical characteristics of Japanese patients with anti-OJ (anti-isoleucyl-tRNA synthetase) autoantibodies
Clinical characteristics of Japanese patients with anti-OJ (anti-isoleucyl-tRNA synthetase) autoantibodies
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DOI：
10.1093/rheumatology/kel435
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发表时间：
2007-05-01
期刊：
影响因子：
5.5
通讯作者：
Hirakata, M.
中科院分区：
文献类型：
--
作者：
Sato, S.;Kuwana, M.;Hirakata, M.
目标.对7例抗氨酰-tRNA合成酶（ARS）自身抗体，特别是抗OJ（抗异亮氨酰-tRNA合成酶）抗体患者的临床和实验室特征进行了检查，并与先前发表的结果进行了比较。从1135例日本患者的血清样本与各种自身免疫性疾病和48名正常人进行了筛选抗OJ抗体使用RNA和蛋白质免疫沉淀试验。对血清中含有抗OJ抗体的患者进行临床症状、临床病程、实验室检查、胸部X线片和胸部CT检查。发现7名患者的血清中含有抗OJ抗体。这些自身抗体与间质性肺病（ILD）和肌炎有关。7例患者的诊断为特发性间质性肺炎（IIP）3例，多发性肌炎（PM）3例，PM-类风湿性关节炎（RA）重叠1例。所有患者均患有ILD，但仅在4例患者中观察到肌肉无力和多关节炎。所有患者均无雷诺氏现象和指硬结。这些结果表明，抗OJ自身抗体的存在可以区分抗ARS综合征的亚型，其与ILD的关系比肌炎或雷诺现象更密切。
Objectives. The clinical and laboratory characteristics of seven patients with anti-aminoacyl-tRNA synthetase (ARS) autoantibodies, specifically anti-OJ (anti-isoleucyl-tRNA synthetase), were examined and compared with previously published findings.Methods. Serum samples from 1135 Japanese patients with various autoimmune diseases and 48 normal individuals were screened for anti-OJ antibodies using RNA and protein immunoprecipitation assays. The patients whose sera contained anti-OJ antibodies were assessed regarding clinical symptoms, clinical course, laboratory findings, chest radiography and chest computed tomography.Results. Sera from seven patients were found to contain anti-OJ antibodies. These autoantibodies were associated with interstitial lung disease (ILD) and myositis. The diagnoses of the seven patients were idiopathic interstitial pneumonias (IIPs) in three, polymyositis (PM) in three and PM-rheumatoid arthritis (RA) overlap in the remaining one. All patients had ILD, but muscle weakness and polyarthritis were seen only in four. Raynaud's phenomenon and sclerodactyly were absent in all patients.Conclusions. These results indicate that the presence of anti-OJ autoantibodies may distinguish a subtype of anti-ARS syndrome that is more closely associated with ILD than myositis or Raynaud's phenomenon.