Risk of smoking and body mass index for incidence of diabetes mellitus in a rural Japanese population
Risk of smoking and body mass index for incidence of diabetes mellitus in a rural Japanese population
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DOI：
10.1016/j.ypmed.2012.02.016
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发表时间：
2012-05-01
影响因子：
5.1
通讯作者：
Watanabe, Shaw
中科院分区：
文献类型：
--
作者：
Morimoto, Akiko;Ohno, Yuko;Watanabe, Shaw
目的：为了评估吸烟的风险，身体质量指数（BMI），和两者的糖尿病发病率在日本农村population.Method：这项研究是一项为期10.1年的队列研究，2070名男性和3802名女性年龄在40-69岁，基线没有糖尿病谁接受了健康检查，在长野县的一个中心医院。参与者根据吸烟状况和BMI进行分类。参与者从1990年到2006年被跟踪。糖尿病的发病率是根据空腹和随机血糖水平、HbA（1c）水平或正在接受糖尿病药物治疗来确定的。结果：在59，111人年的随访中，595名参与者发生了糖尿病。在男性中，与正常体重的非吸烟者相比，糖尿病发病率的多变量校正风险比如下：正常体重的当前吸烟者为3.36（2.02-5.60），肥胖非吸烟者和肥胖当前吸烟者分别为1.70（0.87-3.34）和3.93（2.22-6.96）。在男性中，由于目前的吸烟，肥胖和两者的糖尿病发病的人口归因分数分别为22.0%，2.5%和11.2%，respectively：无论BMI，吸烟是一个重要的危险因素，糖尿病在男性人群中吸烟率高。(C)2012 Elsevier Inc. All rights reserved.
Objective: To assess the risk of smoking, body mass index (BMI), and both for incidence of diabetes in a rural Japanese population.Method: This study was a 10.1-year cohort study of 2070 men and 3802 women aged 40-69 years without diabetes at baseline who underwent a health check-up at one central hospital in Nagano Prefecture. Participants were classified according to a combination of smoking status and BMI. Participants were followed from 1990 to 2006. The incidence of diabetes was determined from fasting and random levels of plasma glucose, HbA(1c) levels or being under medical treatment for diabetes.Results: Diabetes developed in 595 of the participants during 59,111 person-years of follow-up. In men, the multivariable-adjusted hazard ratios for incidence of diabetes compared with non-smokers of normal weight were as follows: 3.36 (2.02-5.60) in current smokers with normal weight and 1.70 (0.87-3.34) and 3.93 (2.22-6.96) in obese non-smokers and obese current smokers, respectively. In men the population-attributable fraction of diabetes onset due to current smoking, obesity and both were 22.0%, 2.5% and 11.2%, respectively.Conclusion: Regardless of BMI, smoking is an important risk factor for diabetes in male populations with a high prevalence of smoking. (C) 2012 Elsevier Inc. All rights reserved.