Reduction in Colon Cancer Risk by Consumption of Kava or Kava Fractions in Carcinogen-Treated Rats
Reduction in Colon Cancer Risk by Consumption of Kava or Kava Fractions in Carcinogen-Treated Rats
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DOI：
10.1080/01635581.2012.689917
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发表时间：
2012-01-01
影响因子：
2.9
通讯作者：
Xing, Chengguo
中科院分区：
文献类型：
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作者：
Triolet, Julie;Shaik, Ahmad Ali;Xing, Chengguo
流行病学研究表明卡瓦可以降低结肠癌的风险。然而，尚未报道卡瓦对结肠癌的化学预防特性的实验研究。此外，人们还担心卡瓦的肝毒性。这项研究的目的是确定卡瓦消费是否会降低动物模型中结肠癌的标志物，并研究卡瓦的安全性。在给予结肠特异性致癌物二甲基肼之前、期间和之后，将乙醇提取物以及卡瓦提取物的极性和非极性部分喂给大鼠12天。 14周后，喂食非极性提取物的大鼠的癌前病变[异常隐窝（AC）病灶（ACF）]以及仅表达唾液酸粘蛋白的大病灶（>= 4 AC/ACF）显着减少，这是与对照组相比具有更大致瘤潜力的指标。喂食乙醇提取物和极性卡瓦酒组分的组倾向于减少 ACF 和仅表达唾液粘蛋白的大灶。与对照组相比，组合卡瓦组的总 AC、ACF、大 ACF 和仅表达唾液粘蛋白的大灶明显较少。组织学检查发现食用卡瓦饮食的动物没有肝脏病变，表明卡瓦可以安全食用。我们的结果支持卡瓦可以降低结肠癌风险。
Epidemiological studies suggest that kava reduces colon cancer risk. However, no experimental studies of the chemopreventive properties of kava toward colon cancer have been reported. Further, there are concerns regarding hepatotoxicity of kava. The goal of this study was to determine whether kava consumption reduces markers of colon cancer in an animal model and to study the safety of kava. An ethanolic extract and polar and nonpolar fractions of the kava extract were fed to rats for 12 days prior to, during, and after administration of dimethylhydrazine, a colon-specific carcinogen. After 14 wk, rats fed the nonpolar extract had a significant reduction in precancerous lesions [aberrant crypt (AC) foci (ACF)] as well as large (>= 4 AC/ACF) sialomucin-only expressing foci, an indicator of greater tumorigenic potential, compared to the control group. Groups fed the ethanolic extract and polar kava fraction trended toward reductions in ACF and large sialomucin-only expressing foci. The combined kava groups had significantly fewer total AC, ACF, large ACF, and large sialomucin-only expressing foci compared to the control group. Histological examination found no hepatic lesions in animals consuming the kava diets, suggesting that kava is safe to consume. Our results support that kava may reduce colon cancer risk.