Neurobehavioral effects of central nervous system prophylactic treatment of cancer in children.
Neurobehavioral effects of central nervous system prophylactic treatment of cancer in children.
复制标题
儿童癌症中枢神经系统预防性治疗的神经行为影响。
DOI：
10.1080/01688638808408255
复制
发表时间：
1988
影响因子：
2.2
通讯作者：
Copeland,DR
中科院分区：
文献类型：
--
作者：
Fletcher,JM;Copeland,DR
This article reviews 41 studies of the effects of prophylactic CNS treatment on the neurobehavioral development of children with cancer. This research is classified according to studies of (a) children in treatment; (b) long-term survivors; and (c) longitudinal follow-ups of children from the time of diagnosis. Studies vary considerably in design, sample, and outcome variables, so firm conclusions regarding the morbidity of CNS prophylaxis are not currently possible. However, the studies do suggest that CNS prophylaxis does impair cognitive development, particularly when cranial radiation therapy is part of the treatment. There is also evidence of greater impairment in younger children and some suggestion of more frequent impairment of non-language skills relative to language skills. The possible relationships among age, radiation, and non-language cognitive skills may be linked to disruption of white matter CNS structures apparent on autopsy and cerebral tomography following treatment.
