Neural basis for reduced executive performance with hypoxic exercise
Neural basis for reduced executive performance with hypoxic exercise
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DOI：
10.1016/j.neuroimage.2017.12.091
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发表时间：
2018-05-01
期刊：
影响因子：
5.7
通讯作者：
Soya, Hideaki
中科院分区：
文献类型：
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作者：
Ochi, Genta;Yamada, Yuhki;Soya, Hideaki
虽然越来越多的证据表明运动对执行功能有积极影响，但这种影响因环境而异。特别是，在低氧环境（低压或常压低氧）中运动，导致氧气供应减少，可能会抑制或消除这种影响。因此，我们进一步探讨低氧运动对执行功能的影响和其潜在的神经机制之间的关系，通过监测皮质激活模式的变化，利用功能近红外光谱（fNIRS）。15名健康受试者在常氧和低氧条件下（吸入氧分数（FIO 2）= 0.135）进行10分钟中等强度运动（50%O-2峰值）前后进行色词Stroop任务（CWST）。在CWST期间，我们使用fNIRS监测前额叶激活。CWST性能在低氧条件下降低与常氧条件下相比。此外，CWST相关激活左背外侧前额叶皮层（DLPFC）后，一轮低氧运动减少。CWST性能下降与左侧DLPFC激活之间存在统计学显著相关性。这些结果表明，在常压缺氧条件下进行适度的运动，通过减少DLPFC中与任务相关的激活，对执行功能产生负面影响。
While accumulating evidence suggests positive effects of exercise on executive function, such effects vary with environment. In particular, exercise in a hypoxic environment (hypobaric or normobaric hypoxia), leading to decreased oxygen supply, may dampen or cancel such effects. Thus, we further explore the relation between the effects of hypoxic exercise on executive function and their underlying neural mechanisms by monitoring changes of cortical activation patterns using functional near-infrared spectroscopy (fNIRS). Fifteen healthy participants performed color-word Stroop tasks (CWST) before and after a 10 min bout of moderate-intensity exercise (50% O-2peak) under normoxic and hypoxic conditions (fraction of inspired oxygen (FIO2) = 0.135). During the CWST, we monitored prefrontal activation using fNIRS. CWST performance under hypoxic conditions decreased compared with normoxic conditions. In addition, CWST-related activation in the left dorsolateral prefrontal cortex (DLPFC) was reduced after a bout of hypoxic exercise. There was statistically significant association between decreased CWST performance and activation in the left DLPFC. These results suggest that moderate exercise under normobaric hypoxic conditions has negative effects on executive function by reducing task-related activations in the DLPFC.