Energy metabolism in the acquisition and maintenance of stemness.
Energy metabolism in the acquisition and maintenance of stemness.
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DOI：
10.1016/j.semcdb.2016.02.010
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发表时间：
2016-04
影响因子：
7.3
通讯作者：
Terzic A
中科院分区：
文献类型：
--
作者：
Folmes CD;Terzic A
能量代谢传统上被认为是一个反应性的稳态系统，解决特定阶段的细胞能量需求。然而，人们越来越认识到代谢途径对重要细胞功能的主动控制。一个恰当的例子是，干细胞的生命周期--从干细胞的维持和获得到谱系定型和特化--越来越多地被认为是一个代谢依赖的过程。事实上，代谢重编程是一个早期的贡献者精心策划的离开或重新获得的干性。代谢组学的最新进展有助于破译的身份和动力学的代谢通量涉及燃料细胞命运的选择，通过调节细胞的表观遗传和转录的身份。代谢线索，内部和/或外部的干细胞生态位，促进祖细胞库恢复，长期组织更新或确保采用细胞保护行为。能量代谢与干细胞命运调控的融合为理解原始发育生物学原理开辟了一条新的途径，并将其应用于再生医学实践。
Energy metabolism is traditionally considered a reactive homeostatic system addressing stage-specific cellular energy needs. There is however growing appreciation of metabolic pathways in the active control of vital cell functions. Case in point, the stem cell lifecycle – from maintenance and acquisition of stemness to lineage commitment and specification – is increasingly recognized as a metabolism-dependent process. Indeed, metabolic reprogramming is an early contributor to the orchestrated departure from or reacquisition of stemness. Recent advances in metabolomics have helped decipher the identity and dynamics of metabolic fluxes implicated in fueling cell fate choices by regulating the epigenetic and transcriptional identity of a cell. Metabolic cues, internal and/or external to the stem cell niche, facilitate progenitor pool restitution, long-term tissue renewal or ensure adoption of cytoprotective behavior. Convergence of energy metabolism with stem cell fate regulation opens a new avenue in understanding primordial developmental biology principles with future applications in regenerative medicine practice.