A CRITICAL REVIEW
A CRITICAL REVIEW
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DOI：
10.1136/jnnp.2.4.335
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发表时间：
1939-10
影响因子：
--
通讯作者：
C. Aring;T. Spies
中科院分区：
文献类型：
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作者：
C. Aring;T. Spies
由于临床、实验和病理学资料的迅速积累，营养不足引起的神经系统损害已占据越来越重要的地位。人工合成维生素B复合物的许多成分，使得大量的纯晶体材料可用于临床研究，因此，这些影响的历史上的一个里程碑已经过去。现在看来，审查和总结这些重要物质的知识是适当的。评估人的营养缺乏状况是困难的。一般来说，病人诱发自己的疾病，并提供一个缺陷，这是无法定量测量，但经常尝试临床和实验室评估。实验室方法和临床方法都有一定的优势。小鼠还不是人类，直到它们成为人类的研究才是至关重要的。由于与动物一起工作的研究人员的经验可能经常为临床研究指明方向，我们在这篇综述中穿插了一些关于营养缺乏对动物神经系统影响的相关研究。图1给出了维生素B复合物的多因素图解。迄今为止，已经分离和合成了维生素B复合物的以下部分，其量足以进行临床试验：盐酸硫胺素、烟酸、核黄素和2-甲基，3-羟基，4，5-二（羟甲基）吡啶。这些物质在应用于人类神经系统时的不足之处将简要讨论。
AFFECTIONS of the nervous system which result from inadequate nutrition have assumed an increasingly important position through the rapid accumulation of clinical, experimental, and pathological data. The artificial synthesis of a number of the components of the vitamin B complex has made available pure crystalline material in large amounts for clinical research, and thus a milestone in the history of these affections has been passed. It now seems appropriate to review and summarize the knowledge of these important substances. To evaluate the status of a nutritional deficiency in man is difficult. As a rule the patient induces his own disease and provides a deficiency that is not quantitatively measurable, but frequently clinical and laboratory evaluations are attempted. Both the laboratory method and the clinical method have certain advantages. Mice are not yet men and until they are the work coming -from the study of human beings is essential. Since the experience of investigators working with animals may often point the way for clinical research, we have interspersed in this review a few of the pertinent studies on the effect of nutritional deficiency on the nervous system of animals. A scheme for illustrating the multiple factors of the vitamin B complex is given in Fig. 1. To date the following portions of the vitamin B complex have been isolated and synthesized in amounts sufficient to allow for clinical trial: thiamin hydrochloride, nicotinic acid, riboflavin, and 2-methyl, 3-hydroxy, 4, 5-di (hydroxymethyl) pyridine. The deficiencies of these substances as they apply to the nervous system of man will be discussed briefly.