Childhood adversities and adult psychopathology in the WHO World Mental Health Surveys
Childhood adversities and adult psychopathology in the WHO World Mental Health Surveys
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DOI：
10.1192/bjp.bp.110.080499
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发表时间：
2010-11-01
影响因子：
10.5
通讯作者：
Williams, David R.
中科院分区：
文献类型：
--
作者：
Kessler, Ronald C.;McLaughlin, Katie A.;Williams, David R.
背景虽然童年逆境与成人精神障碍的显著关联被广泛记录，目的探讨12种儿童期不良事件与世界精神卫生（WMH）DSM-IV版20种首发精神障碍的联合关联在21个国家进行的调查。方法对51945名成年人进行的全国或区域代表性调查评估了儿童期逆境和终身DSM-IV疾病与WHO复合国际诊断Interview（CIDI.ResultsChildhood逆境是高度流行和相互关联的。与适应不良的家庭功能（如父母精神疾病，虐待儿童，忽视）相关的童年逆境是最强的疾病预测因子。与适应不良的家庭功能相关的共同发生的童年逆境具有显着的次加性预测关联，并且在疾病之间几乎没有特异性。儿童期逆境占29.8%的所有障碍across countries.ConclusionsChildhood逆境有很强的关联与所有类别的障碍在所有生命过程中的各个阶段，在所有组的WMH国家。长期关联意味着存在尚未确定的中介。
BackgroundAlthough significant associations of childhood adversities with adult mental disorders are widely documented, most studies focus on single childhood adversities predicting single disorders.AimsTo examine joint associations of 12 childhood adversities with first onset of 20 DSM-IV disorders in World Mental Health (WMH) Surveys in 21 countries.MethodNationally or regionally representative surveys of 51 945 adults assessed childhood adversities and lifetime DSM-IV disorders with the WHO Composite International Diagnostic Interview (CIDI).ResultsChildhood adversities were highly prevalent and interrelated. Childhood adversities associated with maladaptive family functioning (e.g. parental mental illness, child abuse, neglect) were the strongest predictors of disorders. Co-occurring childhood adversities associated with maladaptive family functioning had significant subadditive predictive associations and little specificity across disorders. Childhood adversities account for 29.8% of all disorders across countries.ConclusionsChildhood adversities have strong associations with all classes of disorders at all life-course stages in all groups of WMH countries. Long-term associations imply the existence of as-yet undetermined mediators.