Survival rates of patients with metastatic spinal cancer after scintigraphic detection of abnormal radioactive accumulation
Survival rates of patients with metastatic spinal cancer after scintigraphic detection of abnormal radioactive accumulation
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DOI：
10.1097/00007632-199609150-00017
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发表时间：
1996-09-15
期刊：
影响因子：
3
通讯作者：
Inoue, T
中科院分区：
文献类型：
--
作者：
Tatsui, H;Onomura, T;Inoue, T
研究设计.这项回顾性研究分析了脊柱转移的时间和癌症患者在脊柱转移瘤检测后的生存能力。评估原发病灶脊柱转移的时间和脊柱转移瘤患者的生存率。背景资料摘要。很少有研究分析原发病灶对脊柱转移瘤患者生存率的影响。本文回顾了1980 ~ 1991年在肺癌、乳腺癌、前列腺癌、宫颈癌、肾癌和胃癌患者中连续进行的骨显像。为了排除假阳性病例，通过其他诊断成像方法进一步检查骨X线照片上显示异常积聚的脊柱区域。本文对425例脊柱转移瘤患者的CT检查时机和生存率进行了研究。采用Kaplan-Meier生存曲线确定脊髓蓄积后的生存率。从诊断原发病灶到检测到脊柱异常积聚的平均时间，肺癌最短（3.6 +/- 6.1个月），乳腺癌最长（29.4 +/- 33.5个月）。乳腺癌和前列腺癌的1年生存率较高（分别为78%和83%），肺癌和胃癌的1年生存率较低（分别为22%和0%）。胃癌6个月生存率为15%。在处理转移性脊柱肿瘤时，必须充分考虑原发病灶的特征和预期预后来选择治疗方法。
Study Design. This retrospective study analyzes the timing of spinal metastases and the survivability of patients with cancer after the detection of spinal metastases.Objective. To evaluate the timing of spinal metastases in primary lesions and survivability of patients with metastatic spinal tumors.Summary of Background Data. Few studies have analyzed the influence of primary lesions on survival rates of patients with metastatic spinal tumors.Methods. This is a review of bone scintigraphy that was performed serially in patients with pulmonary cancer, breast cancer, prostatic cancer, cervical cancer, renal cancer, and gastric cancer from 1980 to 1991. To exclude false-positive cases, the spinal areas showing abnormal accumulation on bone scintigrams were further examined by other methods of diagnostic imaging. The timing of scintigraphic detection of spinal metastases and the survivability were studied in 425 patients with spinal metastases. The survivability after spinal accumulation was determined by the Kaplan-Meier survival curve.Results. The mean period, from the diagnosis of the primary lesion to the detection of abnormal accumulation in the spine, was shortest in pulmonary cancer (3.6 +/- 6.1 months), and it was longest in breast cancer (29.4 +/- 33.5 months). The 1-year survival rate was high in breast cancer (78%) and prostatic cancer (83%), and it was low in pulmonary cancer (22%) and gastric cancer (0%), respectively. The 6-month survival rate of gastric cancer was 15%.Conclusions. When managing metastic spinal tumors, it is essential to select therapeutic methods based on adequate consideration of the features of primary lesions and the expected prognosis.