Effect of wild Korean ginseng (Panax ginseng) extract on blood glucose and serum lipid contents in rats with multiple low-dose streptozotocin-induced diabetes
Effect of wild Korean ginseng (Panax ginseng) extract on blood glucose and serum lipid contents in rats with multiple low-dose streptozotocin-induced diabetes
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DOI：
10.1007/s10068-015-0194-9
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发表时间：
2015-08
影响因子：
2.9
通讯作者：
H. Moon;Kil-Soo Kim;Shin-Kyo Chung;Jong-Kuk Kim
中科院分区：
文献类型：
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作者：
H. Moon;Kil-Soo Kim;Shin-Kyo Chung;Jong-Kuk Kim
研究了野高丽参提取物对多次小剂量链脲佐菌素（STZ）诱导的糖尿病大鼠的抗糖尿病作用。以100、200和300 mg/kg体重的剂量对大鼠给予浸提液，持续8周。尽管食物和水的摄入量显著（p<0.05）高于人参治疗的大鼠，但人参未治疗的糖尿病大鼠的体重显著（p<0.05）低于人参治疗的大鼠。在200和300 mg/kg体重的人参治疗的糖尿病大鼠中，血糖水平显著（p <0.05）高于用100 mg人参治疗的大鼠和未治疗的对照大鼠，但血浆胰岛素水平显著（p<0.05）低于用100 mg人参治疗的大鼠和未治疗的对照大鼠。人参高剂量组大鼠血浆天冬氨酸转氨酶水平无明显变化（p>0.05），而丙氨酸转氨酶和碱性磷酸酶水平明显降低（p<0.05）。在多次低剂量STZ诱导的糖尿病大鼠中，通过给予野生高丽参提取物引起抗糖尿病作用。
Anti-diabetic effects of wild Korean ginseng extracts on multiple low-dose streptozotocin (STZ)-induced diabetic rats were investigated. Rats were administered extracts at rates of 100, 200, and 300 mg/kg of body weight for 8 weeks. Body weight was significantly (p<0.05) lower in ginseng untreated diabetic rats than in ginseng treated rats in spite of significantly (p<0.05) higher food and water intake than for ginseng treated rats. Blood glucose levels were significantly (p<0.05) higher but plasma insulin levels were significantly (p<0.05) lower in 200 and 300 mg/kg of body weight ginseng treated diabetic rats than in rats treated with 100 mg of ginseng and in untreated control rats. The plasma aspartate aminotransaminase level was not significantly (p>0.05) affected; however alanine aminotransaminase and alkaline phosphatase levels were reduced significantly (p<0.05) in higher ginseng dosage rat groups. Anti-diabetic effects were elicited by administration of wild Korean ginseng extracts in multiple low-dose STZ-induced diabetic rats.