DETERMINATION OF GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP) IN HUMAN-BRAIN TUMORS
DETERMINATION OF GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP) IN HUMAN-BRAIN TUMORS
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DOI：
10.1016/0022-510x(78)90107-7
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发表时间：
1978-01-01
影响因子：
4.4
通讯作者：
BAUMANN, NA
中科院分区：
文献类型：
--
作者：
JACQUE, CM;VINNER, C;BAUMANN, NA
用火箭电泳技术检测脑肿瘤中GFAP的含量。脑膜瘤和神经鞘瘤GFAP表达较低。转移灶中GFAP表达水平低，除非被周围组织污染。非神经系统肿瘤如骨髓瘤、骨髓瘤和腺癌均为阴性。在神经胶质肿瘤中寻找与组织学观察的更详细的相关性。低水平的GFAP总是与恶性肿瘤的迹象，如有丝分裂和巨大或非典型细胞，而高水平的GFAP与保存完好的星形胶质细胞的存在相关。
Brain tumors were tested for their GFAP content by the rocket electrophoresis technique. Meningiomas and neurinomas were low in GFAP. Metastases had a low level of GFAP except when contaminated with surrounding tissue. Nonnervous tumors such as myeloma, myeloplaxoma and adenocarcinoma gave negative results. More detailed correlations with histological observations were looked for in glial tumors. Low levels of GFAP were always associated with signs of malignancy such as mitoses and giant or atypical cells, whereas high levels of GFAP were correlated with the presence of well-preserved astrocytes.