Plasticity in respiratory motor control - Selected contribution: Intermittent hypoxia induces phrenic long-term facilitation in carotid-denervated rats
Plasticity in respiratory motor control - Selected contribution: Intermittent hypoxia induces phrenic long-term facilitation in carotid-denervated rats
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DOI：
10.1152/japplphysiol.00374.2002
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发表时间：
2003-01-01
影响因子：
3.3
通讯作者：
Mitchell, GS
中科院分区：
文献类型：
--
作者：
Bavis, RW;Mitchell, GS
间歇性低氧引起被称为长期促进(LTF)的膈吸气活动的长期增强。我们在乌拉坦麻醉、迷走神经切断、瘫痪和呼吸的SD大鼠上，观察了颈动脉化学传入神经元的激活和低氧对LTF表达的影响。动脉血氧分压(PaO2)=40+/-5Torr[动脉血氧分压(PaO2)=40+/-5Torr]后1h，颈动脉失神经支配大鼠(n=8)和假手术大鼠(n=7)的膈神经爆发积分波幅均大于基础值(P
Episodic hypoxia elicits a long-lasting augmentation of phrenic inspiratory activity known as long-term facilitation (LTF). We investigated the respective contributions of carotid chemoafferent neuron activation and hypoxia to the expression of LTF in urethane-anesthetized, vagotomized, paralyzed, and ventilated Sprague-Dawley rats. One hour after three 5-min isocapnic hypoxic episodes [arterial PO2 (Pa-O 2) = 40+/-5 Torr], integrated phrenic burst amplitude was greater than baseline in both carotid-denervated (n=8) and sham-operated (n=7) rats (P