SWALEDALE SHEEP AFFECTED BY NATURAL SCRAPIE DIFFER SIGNIFICANTLY IN PRP GENOTYPE FREQUENCIES FROM HEALTHY SHEEP AND THOSE SELECTED FOR REDUCED INCIDENCE OF SCRAPIE
SWALEDALE SHEEP AFFECTED BY NATURAL SCRAPIE DIFFER SIGNIFICANTLY IN PRP GENOTYPE FREQUENCIES FROM HEALTHY SHEEP AND THOSE SELECTED FOR REDUCED INCIDENCE OF SCRAPIE
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DOI：
10.1099/0022-1317-74-6-1025
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发表时间：
1993-06-01
影响因子：
3.8
通讯作者：
HOPE, J
中科院分区：
文献类型：
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作者：
HUNTER, N;GOLDMANN, W;HOPE, J
研究了自然瘙痒病感染的Swaledale绵羊、健康绵羊和低敏感度Swaledale绵羊的PRP糖蛋白基因多态性。限制性内切酶EcoRI、HindIII和BspHI检测到的PrP基因频率在三组间存在显著差异，后者表明PrP蛋白在第136位密码子上存在氨基酸差异。这些频率差异在单群研究中得到了证实，并提供了很好的证据，表明Swaledale绵羊对瘙痒病的易感性和抗药性与PrP基因变异有关。
PrP glycoprotein gene polymorphisms were examined in Swaledale sheep affected by natural scrapie, in healthy sheep and in Swaledales selected for low susceptibility to scrapie. The three groups differed significantly in frequencies of PrP genotypes detected by the restriction enzymes EcoRI, HindIII and BspHI, the latter being indicative of a PrP protein amino acid difference at codon 136. These frequency differences were confirmed in a single-flock study and present good evidence that scrapie susceptibility and resistance are associated with PrP gene variants in Swaledale sheep.