Impact of enriched environment during adolescence on adult social behavior, hippocampal synaptic density and dopamine D2 receptor expression in rats
Impact of enriched environment during adolescence on adult social behavior, hippocampal synaptic density and dopamine D2 receptor expression in rats
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DOI：
10.1016/j.physbeh.2020.113133
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发表时间：
2020-11-01
影响因子：
2.9
通讯作者：
Jeffrey, Rachel
中科院分区：
文献类型：
--
作者：
Gabriel, Paul;Mastracchio, Toni-Ann;Jeffrey, Rachel
环境富集（EE）是一种诱导大脑变化的实验操作。然而，必须区分物质富集和社会富集。为此，我们建立了四组大鼠饲养在不同的丰富的环境中，在青春期。我们的研究结果表明，在社会丰富的动物中，特别是在齿状回中，社会记忆和棘密度增加。物理富集增加CA1的棘密度。在所有富集条件下，海马中的多巴胺D2受体表达均降低。总之，我们的研究结果表明，不同的物理和社会丰富的影响，支持环境中的突触发生，行为和多巴胺能信号的重要作用。
Environmental enrichment (EE) is one experimental manipulation that induces changes in the brain. However, it is important to distinguish between physical and social components of enrichment. To this end we established four groups of rats reared in different enriched environments during the adolescent period. Our results indicate heightened social memory and increased spine density in dentate gyrus specifically in socially enriched animals. Physical enrichment increased spine density in CA1. Dopamine D2 receptor expression in hippocampus was decreased across all enrichment conditions. Altogether, our results demonstrate differing effects of physical and social enrichment, supporting an important role for environment in synaptogenesis, behavior, and dopaminergic signaling.