Biosynthetic Origin of the Ansa-Structure of Ansamitocin P-3
Biosynthetic Origin of the Ansa-Structure of Ansamitocin P-3
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DOI：
10.1271/bbb1961.49.327
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发表时间：
1985-02
期刊：
影响因子：
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通讯作者：
K. Hatano;E. Mizuta;S. Akiyama;E. Higashide;Y. Nakao
中科院分区：
文献类型：
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作者：
K. Hatano;E. Mizuta;S. Akiyama;E. Higashide;Y. Nakao
通过喂入14C-和13c -标记的化合物，研究了ansamitocin P-3结构的生物合成来源。结果表明，该结构由3个直接来源于乙酸酯的c2单元、1个来源于葡萄糖代谢物的c2单元、3个来源于丙酸盐的c3单元和一个来源于葡萄糖代谢物的氨基苯基核组成的长脂肪链构成。该结构中的3个q取代基、2个o -甲基和1个n -甲基分别由甘氨酸的C-2和蛋氨酸的s -甲基组成。由瓜氨酸的氨基甲酰衍生出一种环碳酰胺。f抗菌菌素的发酵生产和生物合成。第二部分。这项工作在日本农业化学学会年会上发表（东京，1982年）。
The biosynthetic origin of the ansa-structure of ansamitocin P-3 was investigated by feeding 14C- and 13C-labeled compounds. The results suggested that the ansa-structure was constructed from a long aliphatic chain composed of three C2-units directly derived from acetate, one C2-unit derived from metabolites of glucose and three C3-units derived from propionate, and an aminobenzenoid nucleus derived from metabolites of glucose. Three Q-substituents, two O-methyl and one N-methyl group in the sructure were derived from the C-2 of glycine and the S-methyl of methionine. A cyclic carbinolamide was derived from the carbamoyl of citrulline.f Fermentative Production and Biosynthesis of Ansamitocins. Part II. This work was presented at the Annual Meeting of the Agricultural Chemical Society of Japan (Tokyo, 1982).