Stroke in young adults: a prospective study from northwestern Nigeria.
Stroke in young adults: a prospective study from northwestern Nigeria.
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DOI：
10.5402/2012/468706
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
Ibrahim A
中科院分区：
文献类型：
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作者：
Owolabi LF;Ibrahim A
背景。中风是年轻人发病和死亡的重要原因，尤其是在发展中国家。这项双中心前瞻性研究旨在回顾尼日利亚西北部年轻人中风的模式、类型和病死率。方法。研究招募了2008年6月至2010年8月连续入住两所三级医院内科病房的18-40岁患者。从患者处获取相关临床资料。幸存者在神经病学门诊随访6个月。结果。共71例患者，年龄18-40岁，平均年龄31.9±6岁，其中男性52例（73%），女性19例（23%）。42例（59.1%）患者发生梗死性卒中。危险因素包括高血压（74.7%）、吸烟（50.7%）、高胆固醇血症（9.9%）、非高血压性心脏病（8.5%）、艾滋病毒（8.5%）、糖尿病（4.2%）、可卡因和安非他明（2.8%）和镰状细胞病（2.8%）。只有12例（17%）患者在中风发作后6小时内出现。死亡17例（23.9%），发病前24小时和72小时病死率分别为4.2%和19.7%。结论。我们的数据表明，年轻人中风并不像以前认为的那样罕见。高血压、吸烟、高胆固醇血症、心脏病和艾滋病毒是最常见的危险因素。
Background. Stroke is an important cause of morbidity and mortality in young adults especially in developing countries. This two-centre prospective study aimed at reviewing the pattern, types, and case fatality of stroke in the young adults in Northwestern part of Nigeria. Methods. Consecutive patients aged 18–40 years admitted to the medical wards of two tertiary hospitals from June 2008 to August 2010 were recruited. Relevant clinical data were obtained from the patients.The survivors were followed up in neurology clinics for 6 months. Results. A total of 71 patients aged 18–40 yrs, (mean age was 31.9 ± 6) comprising 52(73%) males and 19(23%) females were enrolled. Forty two (59.1%) patients had infarctive stroke. The risk factors included hypertension (74.7%) patients, smoking (50.7%), hypercholesterolemia (9.9%), non-hypertensive cardiac diseases (8.5%), HIV (8.5%), diabetes mellitus (4.2%) cocaine and amphetamine (2.8%), and sickle cell disease (2.8%). Only twelve (17%) patients presented within the first 6 hours of onset of stroke. Seventeen (23.9 %) patients died, case fatality in the first 24 and 72 hrs was 4.2% and 19.7%, respectively. Conclusion. Our data suggests that stroke in young adults is not as uncommon as previously suggested. Hypertension, smoking, hypercholesterolemia, cardiac diseases and HIV are the most common risk factors.