Position reconstruction from an ensemble of hippocampal place cells: Contribution of theta phase coding
Position reconstruction from an ensemble of hippocampal place cells: Contribution of theta phase coding
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DOI：
10.1152/jn.2000.83.5.2602
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发表时间：
2000-05-01
影响因子：
2.5
通讯作者：
Lisman, JE
中科院分区：
文献类型：
--
作者：
Jensen, O;Lisman, JE
先前对单个大鼠海马位置细胞放电的分析表明，当它们进入位置场时，它们的放电速率增加，并且当大鼠穿过所保持的位置时，它们相对于正在进行的θ振荡（7-12 Hz）的放电相位系统地变化，这种现象称为θ相位进动。为了研究相位编码和速率编码信息的相对贡献，我们使用同时记录的38个海马神经元的尖峰信号重建了动物在线性轨道上的位置。以前的两项研究发现，没有证据表明，相位信息大大提高重建精度。我们已经发现，重建得到改善，提供了大的，系统性的错误，首先被排除在外的时代。在这种情况下，与仅使用稀有信息相比，使用相位和速率信息两者将重建精度提高了>43%。此外，可以以非常高的精度（误差为
Previous analysis of the firing of individual rat hippocampal place cells has shown that their firing rate increases when they enter a place field and that their phase of firing relative to the ongoing theta oscillation (7-12 Hz) varies systematically as the rat traverses the place held, a phenomenon termed the theta phase precession. To study the relative contribution of phased-coded and rate-coded information, we reconstructed the animal's position on a linear track using spikes recorded simultaneously from 38 hippocampal neurons. Two previous studies of this kind found no evidence that phase information substantially improves reconstruction accuracy. We have found that reconstruction is improved provided epochs with large, systematic errors are first excluded. With this condition, use of both phase and rate information improves the reconstruction accuracy by >43% as compared with the use of rare information alone. Furthermore, it becomes possible to predict the rat's position on a 204-cm track with very high accuracy (error of