Diamond-like carbon coating and plasma or glow discharge treatment of mechanical heart valves.
Diamond-like carbon coating and plasma or glow discharge treatment of mechanical heart valves.
复制标题
DOI：
10.1080/089419399272520
复制
发表时间：
1999-05
期刊：
影响因子：
--
通讯作者：
H. Tran;M. Puc;Charles W. Hewitt;D. Soll;S. Marra;Vincent A. Simonetti;J. Cilley;A. Delrossi
中科院分区：
文献类型：
--
作者：
H. Tran;M. Puc;Charles W. Hewitt;D. Soll;S. Marra;Vincent A. Simonetti;J. Cilley;A. Delrossi
所有机械心脏瓣膜（MHV）均具有血栓形成性。应用表面改性技术降低MHV血栓形成的发生率是一项新的事业。这需要生物工程和心胸外科领域的合作。通过回顾最近和过去的研究结果，以及我们自己对MHV的类金刚石涂层（DLC）和等离子体或辉光放电处理（GDT）的初步研究，我们确定并讨论了几种可能通过表面改性降低瓣膜相关血栓形成程度的潜在有益效果。DLC和GDT可能以多种方式影响MHV的表面，包括清洁有机和无机碎片，在表面层上产生反应性和官能团而不影响其整体性质，并使表面更粘附于内皮细胞和白蛋白，而较少粘附于血小板。表面改性的这些不同效果，单独或组合，可以将MHV的表面转化为在血管系统中更具抗血栓性。
All mechanical heart valves (MHV) are thrombogenic. Application of surface modification technology to reduce the incidence of thrombus formation on MHV is a novel undertaking. This requires collaboration within the bioengineering and cardiothoracic surgery fields. From reviewing results of recent and past investigations, and our own preliminary study with diamond-like carbon coating (DLC) and plasma or glow discharge treatment (GDT) of MHV, we identify and discuss several potentially beneficial effects that may reduce the extent of valve-related thrombogenesis by surface modification. DLC and GDT may affect the surfaces of MHV in many ways, including cleaning of organic and inorganic debris, generating reactive and functional groups on the surface layers without affecting their bulk properties, and making the surfaces more adherent to endothelial cells and albumin and less adherent to platelets. These different effects of surface modification, separately or in combination, may transform the surfaces of MHV to be more thromboresistant in the vascular system.