Differentiated norepinephrine spillover in human skeletal muscle.
Differentiated norepinephrine spillover in human skeletal muscle.
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人体骨骼肌中分化的去甲肾上腺素溢出。
DOI：
10.1152/ajpregu.1997.273.1.r16
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Peter Friberg
中科院分区：
文献类型：
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作者：
A. Karlsson;Mikael Elam;Peter Lönnroth;L. Sullivan;Peter Friberg
大多数神经生理学研究表明，手臂和腿部的交感神经流出相似。然而，一些直接的显微神经摄影记录表明，在休息和精神压力时，四肢的交感神经流出分化。因此，差异化水平的去甲肾上腺素（NE）溢出可能占上风。通过稳态输注[3 H]NE和双能X线吸收测定扫描的身体成分测定，我们同时评估了与100 g组织和总肢体重量相关的手臂和腿部NE溢出。NE溢出在腿部低于手臂（0.26 vs. 1.51 pmol.min-1.100 g-1，P < 0.05），当表示为肢体总重量的函数时，差异仍然存在（66 vs. 137 pmol/min，P < 0.05）。[3 H]NE的提取分数在手臂和腿部相似。去甲丙咪嗪对下肢的神经元摄取阻断效果优于上肢;下肢的NE提取分数降低了32%（P < 0.05），而上肢无明显变化，因此下肢的NE溢出低于上肢，这可能反映了交感神经流出量较低，神经元依赖性更强。
Most neurophysiological studies have shown similar sympathetic outflow to arm and leg. However, some direct microneurographic recordings indicate differentiated sympathetic outflow to limbs both at rest and during mental stress. Hence, differentiated levels of norepinephrine (NE) spillover could prevail. By steady-state infusion of [3H]NE and body composition determination by dual-energy X-ray absorptiometry-scan, we simultaneously assessed arm and leg NE spillover related to 100 g tissue and total limb weight. NE spillover was lower in leg than arm (0.26 vs. 1.51 pmol.min-1.100 g-1, P < 0.05), and the difference remained when expressed as a function of total limb weight (66 vs. 137 pmol/min, P < 0.05). Fractional extraction of [3H]NE was similar in arm and leg. Neuronal uptake blockade by desipramine was more effective in leg than arm; fractional extraction in leg decreased by 32% (P < 0.05) but was unaltered in arm. Thus a lower NE spillover was observed from leg than arm, possibly reflecting a lower sympathetic outflow and a more neuronally dependent reuptake.