Clinical Definitions of Sarcopenia and Risk of Hospitalization in Community-Dwelling Older Men: The Osteoporotic Fractures in Men Study
Clinical Definitions of Sarcopenia and Risk of Hospitalization in Community-Dwelling Older Men: The Osteoporotic Fractures in Men Study
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DOI：
10.1093/gerona/glw327
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发表时间：
2017-10-01
影响因子：
5.1
通讯作者：
Ensrud, Kristine E.
中科院分区：
文献类型：
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作者：
Cawthon, Peggy M.;Lui, Li-Yung;Ensrud, Kristine E.
背景资料：各种定义的肌肉减少症和住院治疗之间的关联尚未评估在社区居住的老年mes.Methods：我们使用的数据来自1,516名参与者在访问3的男性骨质疏松性骨折（MrOS）的研究谁也链接医疗保险费为服务索赔数据。我们使用两部分（“障碍”）模型，根据年龄、临床中心、功能限制、自我报告的健康状况、合并症和认知功能进行调整，研究了几种肌肉减少症定义（国际工作组、老年人肌肉减少症欧洲工作组、NIH肌肉减少症项目基金会、Baumgartner和纽曼）与住院之间的关系。预测因素包括肌肉减少状态（缓慢、虚弱和/或瘦体重的概括定义和组成部分）;结果包括第3次访视检查后3年内的住院和累积住院天数/年。在考虑混杂因素后，总结定义或定义组件均未（缓慢、虚弱或低瘦体重）与住院的可能性、住院患者中住院天数的比率或所有参与者中住院天数的平均比率相关。肌肉减少症与社区老年男性住院无关。这些结果提供了进一步的证据，目前的肌肉减少症的定义是不可能确定那些谁是最有可能有更多的住院治疗。
Background: The association between various definitions of sarcopenia and hospitalization has not been evaluated in community-dwelling older men.Methods: We used data from 1,516 participants at Visit 3 of the Osteoporotic Fractures in Men (MrOS) study who also had linked Medicare Fee-For-Service Claims data available. We examined the association between several sarcopenia definitions (International Working Group, European Working Group for Sarcopenia in Older Persons, Foundation for the NIH Sarcopenia Project, Baumgartner, and Newman) and hospitalization, using two-part ("hurdle") models, adjusted for age, clinical center, functional limitations, self-reported health, comorbidity, and cognitive function. Predictors included sarcopenia status (the summary definitions and the components of slowness, weakness, and/or lean mass); outcomes included hospitalization and cumulative inpatient days/year in the 3 years following the Visit 3 exam.Results: After accounting for confounding factors, none of the summary definitions or the definition components (slowness, weakness, or low lean mass) were associated with likelihood of hospitalization, the rate ratio of inpatient days among those hospitalized, or the mean rate of inpatient days amongst all participants.Conclusions: Sarcopenia was not associated hospitalization in community-dwelling older men. These results provide further evidence that current sarcopenia definitions are unlikely to identify those who are most likely to have greater hospitalization.