LSD-INDUCED ALTERATIONS OF LOCOMOTOR PATTERNS AND EXPLORATION IN RATS
LSD-INDUCED ALTERATIONS OF LOCOMOTOR PATTERNS AND EXPLORATION IN RATS
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DOI：
10.1007/bf00431945
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发表时间：
1982-01-01
影响因子：
3.4
通讯作者：
GEYER, MA
中科院分区：
文献类型：
--
作者：
ADAMS, LM;GEYER, MA
使用免费探索测试来检查 LSD 对新环境中的调查反应和运动活动的影响。在将大鼠放入家庭笼中之前，给大鼠注射 20-30 μg/kg LSD 或盐水。 10分钟后，打开一扇门，进入一个更大的洞板室，在那里监测交叉、后立、洞戳和运动路线。当在测试前 10 或 30 分钟施用时，LSD 仅在 1 小时会话的前半部分减少了在洞板室中花费的时间，从而导致所有洞板活动测量值相应减少。在接下来的 30 分钟内，LSD 治疗的大鼠保持了稳定的反应水平，而对照组的反应则持续下降。尽管LSD治疗的老鼠最初避开了洞板，但在整个1小时的治疗过程中，LSD治疗的老鼠始终在地板洞中戳出更长的洞，并且表现出比对照组更多样化的运动模式。最引人注目的是，接受 LSD 治疗的大鼠未能建立从家笼到洞板各个部分的刻板旅行路线（对照组的特征）。 LSD 可能会通过延缓行为习惯的速度来增强对新环境的恐惧（回避）和调查反应。
A free exploration test was used to examine the effects of LSD on investigatory responding and locomotor activity in a novel environment. Rats were injected with 20-30 .mu.g/kg LSD or saline prior to being placed in a home cage. After 10 min, a door was opened permitting entry into a larger holeboard chamber where crossovers, rearings, hole pokes and routes of locomotion were monitored. When administered either 10 or 30 min prior to testing, LSD reduced the time spent in the holeboard chamber only during the 1st half of a 1-h session, resulting in a corresponding reduction in all holeboard activity measures. In the subsequent 30 min, LSD-treated rats maintained a steady level of responding, in contrast to the continual decrement exhibited by controls. Despite their initial avoidance of the holeboard, LSD-treated rats made consistently longer hole pokes into floor holes and showed a more diversified pattern of locomotion than did controls throughout the 1-h session. Most striking was the failure of LSD-treated rats to establish the stereotyped excursion routes, characteristic of controls, from the home cage to various parts of the holeboard. LSD may potentiate both neophobic (avoidance) and investigatory responses to a novel environment by retarding the rate of behavioral habituation.