Endogenous opioid peptides in parasympathetic, sympathetic and sensory nerves in the guinea-pig heart
Endogenous opioid peptides in parasympathetic, sympathetic and sensory nerves in the guinea-pig heart
复制标题
豚鼠心脏副交感神经、交感神经和感觉神经中的内源性阿片肽
DOI：
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发表时间：
1996
影响因子：
3.6
通讯作者：
B. Riederer
中科院分区：
文献类型：
--
作者：
P. Steele;E. Aromataris;B. Riederer
Abstract.Research has suggested that exogenous opi- oid substances can have direct effects on cardiac muscle or influence neurotransmitter release via presynaptic modulation of neuronal inputs to the heart. In the present study, multiple-labelling immunohistochemistry was employed to determine the distribution of endogenous opioid peptides within the guinea-pig heart. Approximately 40% of cardiac ganglion cells contained immunoreactivity for dynorphin A (1–8), dynorphin A (1–17) and dynorphin B whilst 20% displayed leu-enkephalin immunoreactivity. Different populations of opioid-containing ganglion cells were identified according to the co-existence of opioid immunoreactivity with immunoreactivity for somatostatin and neuropeptide Y. Immunoreactivity for prodynorphin-derived peptides was observed in many sympathetic axons in the heart and was also observed, though to a lesser extent, in sensory axons. Leu-enkephalin immunoreactivity was observed in occasional sympathetic and sensory axons. No immunoreactivity was observed for met-enkephalin-arg-gly-leu or for beta-endorphin. These results demonstrate that prodynorphin-derived peptides are present in parasympathetic, sympathetic and sensory nerves within the heart, but suggest that only the prodynorphin gene is expressed in guinea-pig cardiac nerves. This study has shown that endogenous opioid peptides are well placed to regulate cardiac function via both autonomic and sensory pathways.
心脏前脑啡肽原 mRNA 的翻译和培养心肌细胞脑啡肽肽的分泌。
DOI：
10.1152/ajpheart.1992.263.5.h1560
发表时间：
1992
期刊：
The American journal of physiology
影响因子：
--
作者：
Springhorn,JP;Claycomb,WC
通讯作者：
Claycomb,WC