Rapid chiral assembly of rigid DNA building blocks for molecular nanofabrication
Rapid chiral assembly of rigid DNA building blocks for molecular nanofabrication
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DOI：
10.1126/science.1120367
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发表时间：
2005-12-09
期刊：
影响因子：
56.9
通讯作者：
Turberfield, AJ
中科院分区：
文献类型：
--
作者：
Goodman, RP;Schaap, IAT;Turberfield, AJ
用于三维分子纳米织物的实用组件必须易于生产、立体纯、刚性和适应性强。我们报道了一个DNA四面体家族，边长小于10纳米，可以在几秒钟内自组装，并且几乎定量地产生一种非对映体。它们可以通过可编程的DNA接头连接。它们的三角形结构赋予结构稳定性;通过用原子力显微镜压缩DNA四面体，我们测量了DNA的轴向可压缩性，并观察了高载荷下双螺旋的屈曲。
Practical components for three-dimensional molecular nanofabrication must be simple to produce, stereopure, rigid, and adaptable. We report a family of DNA tetrahedra, less than 10 nanometers on a side, that can self-assemble in seconds with near-quantitative yield of one diastereomer. They can be connected by programmable DNA linkers. Their triangulated architecture confers structural stability; by compressing a DNA tetrahedron with an atomic force microscope, we have measured the axial compressibility of DNA and observed the buckling of the double helix under high loads.