The permeability transition and BCL-2 family proteins in apoptosis: co-conspirators or independent agents?
The permeability transition and BCL-2 family proteins in apoptosis: co-conspirators or independent agents?
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DOI：
10.1038/sj.cdd.4401957
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发表时间：
2006-08-01
影响因子：
12.4
通讯作者：
Bernardi, P.
中科院分区：
文献类型：
--
作者：
Forte, M.;Bernardi, P.
本文对细胞程序性死亡中的通透性转换和Bcl-2家族蛋白进行了综述。大多数脊椎动物的异位过程涉及线粒体外膜的透化，导致在线粒体膜之间激活的多种蛋白质的释放，例如异位级联中的蛋白质。有人强调，提出外部直接透化取决于Bcl-2家族蛋白成员的作用。
The article discusses on the permeability transition and Bcl-2 family proteins in the programmed death of cells. The apoptopic process in most vertebrates involves the permeabilization of the outer mitochodrial membrane resulting in the release of a variety of proteins activating between the mitochondrial membranes such as proteins in the apoptopic cascades. It was emphasized that the outer direct permeabilization is proposed to depend on the action of members of Bcl-2 family proteins.