Sentinel lymph node biopsy in oral cavity squamous cell carcinoma without clinically evident metastasis
Sentinel lymph node biopsy in oral cavity squamous cell carcinoma without clinically evident metastasis
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DOI：
10.1002/hed.10355
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发表时间：
2004-01-01
影响因子：
2.9
通讯作者：
Atula, T
中科院分区：
文献类型：
--
作者：
Kontio, R;Leivo, I;Atula, T
背景临床上无颈部口腔鳞状细胞癌的住院患者通常是通过颈淋巴结清扫术治疗，因为不能排除转移的存在。为了确定是否可以避免不必要的治疗，我们评估的可行性前哨淋巴结（SLN）biopsization.Methods，15个以前未经治疗的T1或T2口腔鳞癌没有临床或放射学检测转移的患者。使用蓝色染料和γ探针鉴定SLN。SLN用细胞角蛋白染色。所有颈淋巴结标本均行H & E染色。14例患者通过淋巴管造影识别出前哨淋巴结，所有患者结合探针和染料时均识别出前哨淋巴结。4例颈清扫标本含有4个转移性淋巴结。4个淋巴结中3个为SLN。一个SLN被发现是转移后免疫染色。然而，尽管在一个颈部有一个蓝色前哨淋巴结，但存在转移性非SLN。我们的研究结果表明，SLN活检是一个有前途的工具，用于口腔鳞状细胞癌患者。然而，还需要进一步的研究。(C)2004 Wiley Periodicals，Inc.
Background. The clinically NO neck inpatients with oral SCC is commonly treated by neck dissection because the existence of metastases cannot be excluded. To determine whether unnecessary treatment could be avoided, we evaluated the feasibility of sentinel lymph node (SLN) biopsy.Methods, Fifteen previously untreated patients with T1 or T2 oral SCC without clinically or radiologically detectable metastasis were included. A blue dye and gamma probe were used to identify SLNs. SLNs were stained with cytokeratins. All nodes in neck dissection specimens were stained using H & E.Results. SLNs were identified in 14 patients by lymphoscintigraphy and in all patients when probe and dye were combined. Four neck dissection specimens contained four metastatic lymph nodes. Three of the four lymph nodes were SLN. One SLN was found to be metastatic after immunostaining. However, although there was one blue sentinel node in one neck, a metastatic non-SLN was present.Conclusions. Our results show that SLN biopsy is a promising tool for use in patients with oral SCC. However, further studies are necessary. (C) 2004 Wiley Periodicals, Inc.