Gross vertebral collapse associated with long-term disodium etidronate treatment for pelvic Paget's disease
Gross vertebral collapse associated with long-term disodium etidronate treatment for pelvic Paget's disease
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DOI：
10.1007/s002560050608
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发表时间：
2000-05-01
影响因子：
2.1
通讯作者：
Stamp, TCB
中科院分区：
文献类型：
--
作者：
MacGowan, JR;Pringle, J;Stamp, TCB
骨骼矿化的抑制是一种公认的替地酸二钠治疗的并发症，这在其用于骨质疏松症和佩吉特病的早期研究中得到了证实。与骨质疏松症相比，在佩吉特病中使用较低剂量的效果。在Paget患者未受影响的骨骼中发生自发性骨折的几个病例已经被报道过。然而，我们认为本文所描述的病例是文献中发表的依地膦酸盐诱导的骨软化症最严重的例子，其特点是由于孤立的半骨盆佩吉特病近10年不间断的依地膦酸盐治疗导致椎体塌陷。
Inhibition of skeletal mineralisation is a well-recognized complication of disodium etidronate therapy that was identified in the earliest studies of its use in osteoporosis and Paget's disease. The effect is seen at lower doses in Paget's disease than in osteoporosis. Several cases of spontaneous fractures occurring in unaffected bones of Paget's patients have been reported. However, we believe the case described here is the most severe example of etidronate-induced osteomalacia published in the literature, featuring widespread vertebral collapse occurring as a consequence of nearly 10 years of uninterrupted etidronate treatment for isolated hemipelvic Paget's disease.