RELEASE AND EXCRETION OF METAL IN PATIENTS WHO HAVE A TOTAL HIP-REPLACEMENT COMPONENT MADE OF TITANIUM-BASE ALLOY
RELEASE AND EXCRETION OF METAL IN PATIENTS WHO HAVE A TOTAL HIP-REPLACEMENT COMPONENT MADE OF TITANIUM-BASE ALLOY
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DOI：
10.2106/00004623-199173100-00005
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发表时间：
1991-12-01
影响因子：
5.3
通讯作者：
GALANTE, JO
中科院分区：
文献类型：
--
作者：
JACOBS, JJ;SKIPOR, AK;GALANTE, JO
测量了两种不同设计之一的功能良好的非骨水泥型初次全髋关节置换术患者、需要翻修的松动全髋关节置换术患者和没有植入物的对照受试者的钛、铝和钒的血清浓度和尿排泄。与对照受试者的值相比，植入物松动的患者的血清钛浓度升高约两倍。在所研究的任何组中，未观察到尿钛浓度、血清铝浓度或尿铝浓度方面的重大差异。钒的浓度在所有groups.CLINICAL RELEVANCE一致低：有很多关于可能的毒性作用的金属释放骨科植入物，特别是骨水泥全关节置换组件的关注。在本研究中，接受钛基合金松动全髋关节置换术的患者血清钛浓度升高。该发现的毒理学重要性尚不清楚。在本研究中，与同期对照受试者相比，接受钛基合金全髋关节置换组件的患者血清或尿液中铝的浓度（已充分证明其具有毒性作用）并未升高。
Serum concentration and urinary excretion of titanium, aluminum, and vanadium were measured for patients who had a well functioning cementless primary total hip replacement of one of two different designs, for patients who had a loose total hip replacement that was to be revised, and for control subjects who had no implant. Serum concentrations of titanium were elevated approximately twofold in the patients who had a loose implant, compared with the values for the control subjects. No major differences in terms of urine concentration of titanium, serum concentration of aluminum, or urine concentration of aluminum were observed among any of the groups that were studied. Concentrations of vanadium were uniformly low in all groups.CLINICAL RELEVANCE: There is much concern regarding the possibly toxic effects of the release of metal from orthopaedic implants, particularly cementless total joint-replacement components. In the present study, patients who had a loose total hip replacement of titanium-base alloy had an increased serum concentration of titanium. The toxicological importance of this finding is not known. The concentration of aluminum, which has well documented toxic effects, in the serum or urine of patients who had a total hip-replacement component of titanium-base alloy was not elevated in comparison with contemporaneous control subjects in this study.