Synthesis of maremycins A and D1 via cycloaddition of a nitrone with (E)-3-ethylidene-1-methylindolin-2-one.
Synthesis of maremycins A and D1 via cycloaddition of a nitrone with (E)-3-ethylidene-1-methylindolin-2-one.
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DOI：
10.1021/ol800515w
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发表时间：
2008-04
期刊：
影响因子：
5.2
通讯作者：
T. Ueda;Mitsuhide Inada;I. Okamoto;N. Morita;O. Tamura
中科院分区：
文献类型：
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作者：
T. Ueda;Mitsuhide Inada;I. Okamoto;N. Morita;O. Tamura
以(E)-3-亚乙基-1-甲基吲哚-2-酮为关键步骤，通过手性环硝酮的环加成反应合成了毛霉素A和D_1。该合成明确了毛霉素类化合物的立体化学结构，适合大规模合成用于生物筛选。
A concise synthesis of maremycins A and D1 has been accomplished via cycloaddition of a chiral cyclic nitrone with ( E)-3-ethylidene-1-methylindolin-2-one as a key step. This synthesis clarifies the stereochemistry of the maremycins and is suitable for large-scale synthesis for biological screening.