Sleep Disturbance, Diabetes, and Cardiovascular Disease in Postmenopausal Veteran Women
Sleep Disturbance, Diabetes, and Cardiovascular Disease in Postmenopausal Veteran Women
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DOI：
10.1093/geront/gnv668
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发表时间：
2016-02-01
期刊：
影响因子：
5.7
通讯作者：
Weitlauf, Julie C.
中科院分区：
文献类型：
--
作者：
Rissling, Michelle B.;Gray, Kristen E.;Weitlauf, Julie C.
研究目的：比较妇女健康倡议（WHI）中绝经后退伍军人和非退伍军人参与者睡眠障碍的患病率和心脏代谢健康影响。设计和方法：五类睡眠障碍的患病率-睡眠药物/酒精使用;失眠风险;睡眠呼吸障碍[SDB]风险;共病失眠和SDB风险（失眠+ SDB）;和异常睡眠持续时间[SLD]-在3,707名退伍军人和141,354名非退伍军人中使用logistic或多项式回归进行比较。考克斯比例风险模型被用来评估睡眠障碍和事件心血管疾病（CVD）和2型糖尿病在退伍军人和non-Veterans.Results的关联：女性退伍军人更有可能有失眠+ SDB相对于非退伍军人参与者的高风险。然而，其他形式的睡眠障碍的患病率在各组中相似。基线睡眠障碍与退伍军人与非退伍军人妇女的心脏代谢健康结局无差异相关性。SDB和失眠+ SDB的风险都与心血管疾病和糖尿病的风险增加; SLD一直与更大的风险心血管疾病和糖尿病在非退伍军人，但不太强烈，一贯在Veterans.Implications：努力识别和治疗睡眠障碍的绝经后妇女是必要的，并可能积极有助于心脏代谢疾病的发病风险衰减。提高认识的妇女退伍军人的脆弱性绝经后失眠+ SDB可能是特别重要的医疗保健提供者谁治疗这一人群。
Purpose of the Study: To compare the prevalence and cardiometabolic health impact of sleep disturbance among post-menopausal Veteran and non-Veteran participants in the Women's Health Initiative (WHI).Design and Methods: The prevalence of five categories of sleep disturbance-medication/alcohol use for sleep; risk for insomnia; risk for sleep disordered breathing [SDB]; risk for comorbid insomnia and SDB (insomnia + SDB); and aberrant sleep duration [SLD]-was compared in 3,707 Veterans and 141,354 non-Veterans using logistic or multinomial regression. Cox proportional hazards models were used to evaluate the association of sleep disturbance and incident cardiovascular disease (CVD) and Type 2 diabetes in Veterans and non-Veterans.Results: Women Veterans were more likely to have high risk for insomnia + SDB relative to non-Veteran participants. However, prevalence of other forms of sleep disturbance was similar across groups. Baseline sleep disturbance was not differentially associated with cardiometabolic health outcomes in Veteran versus non-Veteran women. Risks for SDB and insomnia + SDB were both linked to heightened risk of CVD and diabetes; SLD was consistently linked with greater risk of CVD and diabetes in non-Veterans but less strongly and consistently in Veterans.Implications: Efforts to identify and treat sleep disturbances in postmenopausal women are needed and may positively contribute to the attenuation of cardiometabolic morbidity risk. Increased awareness of women Veterans' vulnerability to postmenopausal insomnia + SDB may be particularly important for health care providers who treat this population.