Acute pancreatitis in five European countries:: Etiology and mortality
Acute pancreatitis in five European countries:: Etiology and mortality
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DOI：
10.1097/00006676-200204000-00003
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发表时间：
2002-04-01
期刊：
影响因子：
2.9
通讯作者：
Beger, H
中科院分区：
文献类型：
--
作者：
Gullo, L;Migliori, M;Beger, H
简介：近年来，在急性胰腺炎的诊断和治疗方面取得了许多进展，使发病率和死亡率显著降低;然而，对病因学以及病因学与死亡率之间关系的认识还远未完全。目的：获得比以往单中心研究更全面的关于欧洲急性胰腺炎病因学和死亡率的观点。方法：该研究包括1990年1月至1994年12月期间在五个欧洲国家因急性胰腺炎住院的1，068名患者。结果：在1,068例患者中（692例男性，376例女性;平均年龄，52.8岁;范围，10-95岁），589例水肿性胰腺炎，479例坏死性胰腺炎。胆石症（37.1%）和酒精（41.0%）是最常见的病因。在德国，胆石症和酒精的发生频率相似（分别为34.9%和37.9%）;在匈牙利，酒精主要是胆石症（60.7 vs. 24.0%）;在法国，观察到酒精的少量优势（38.5 vs. 24.6%）;在希腊和意大利，胆石症明显多于酒精（分别为71.4 vs. 6.0%和60.3 vs. 13.2%）。希腊与意大利及其他国家之间胆石症和饮酒的频率差异有统计学意义（p < 0.01）。83例患者（7.8%）死于急性胰腺炎; 77例（16.1%）有坏死性疾病，6例（1.0%）水肿。有没有统计学上的显着差异，死亡率之间的病因组，死亡率和年龄之间没有关系被发现。结论：胆石症和酒精的主要病因因素，在更多的北方国家的研究，而胆石症单独占主导地位，在更南部的。坏死性胰腺炎的死亡率很高，不同病因组之间的死亡率相似，死亡率与年龄无关。
Introduction: In recent years, many advances have been made in the diagnosis and treatment of acute pancreatitis that have lead to a significant reduction in both morbidity and mortality; however, knowledge of the etiology and of the relation between etiology and mortality is far from complete.Aim: To obtain a more comprehensive view of the etiology and mortality of acute pancreatitis in Europe than has been given by previous single-center studies.Methodology: The study comprised 1,068 patients in five European countries who were admitted to hospitals for acute pancreatitis from January 1990 to December 1994. Data for each patient were collected on a standardized form.Results: Of the 1,068 patients (692 men, 376 women; mean age, 52.8 years; range, 10-95 years), 589 had edematous pancreatitis, and 479 the necrotic form. Cholelithiasis (37.1%) and alcohol (41.0%) were the most frequent etiologic factors. In Germany, cholelithiasis and alcohol occurred with similar frequency (34.9 and 37.9%, respectively); in Hungary, alcohol predominates over cholelithiasis (60.7 vs. 24.0%); in France, a small predominance of alcohol was seen (38.5 vs. 24.6%); and in Greece and Italy, there was a clear predominance of cholelithiasis over alcohol (71.4 vs. 6.0% and 60.3 vs. 13.2%, respectively). The differences in the frequency of cholelithiasis and alcohol between Greece and Italy and the other countries were statistically significant (p < 0.01). Eighty-three patients (7.8%) died of acute pancreatitis; 77 (16.1%) had necrotic disease and 6 (1.0%) edematous. There was no statistically significant difference in mortality among the etiologic groups, and no relation was found between mortality and age.Conclusion: Both cholelithiasis and alcohol were main etiologic factors in the more northern countries studied, whereas cholelithiasis alone predominated in the more southern ones. Mortality was high for necrotic pancreatitis; it was similar among the various etiologic groups, and there was no relationship between mortality and age.