Combinations of radiation therapy and immunotherapy for melanoma: a review of clinical outcomes.
Combinations of radiation therapy and immunotherapy for melanoma: a review of clinical outcomes.
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DOI：
10.1016/j.ijrobp.2013.08.035
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发表时间：
2014-04-01
期刊：
影响因子：
--
通讯作者：
Postow MA
中科院分区：
文献类型：
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作者：
Barker CA;Postow MA
放射治疗长期以来在黑色素瘤的管理中发挥着作用。最近的进展也证明了免疫疗法在治疗黑色素瘤中的功效。临床前数据表明放射治疗和免疫治疗之间存在生物学相互作用。一些临床研究证实了这些发现。本综述将总结黑色素瘤患者接受放疗和免疫治疗联合治疗的研究结果。疫苗疗法通常使用辐照过的黑色素瘤细胞，并且可以通过放射疗法来增强。在几项小型研究中，细胞因子干扰素-α和白细胞介素-2已与放射治疗联合使用，一些证据表明毒性和/或疗效增加。Ipilimumab是一种阻断细胞毒性T淋巴细胞抗原-4的单克隆抗体，已在几个值得注意的病例研究和系列中与放射治疗相结合。最后，过继细胞转移的初步研究表明，放射治疗可能会提高治疗效果。该综述将表明，放射治疗和免疫治疗的组合已在几个著名的病例研究，系列和临床试验中报道。这些临床结果表明相互作用和需要进一步研究。
Radiotherapy has long played a role in the management of melanoma. Recent advances have also demonstrated the efficacy of immunotherapy in the treatment of melanoma. Preclinical data suggest a biologic interaction between radiotherapy and immunotherapy. Several clinical studies corroborate these findings. This review will summarize the outcomes of studies reporting on patients with melanoma treated with a combination of radiotherapy and immunotherapy. Vaccine therapies often use irradiated melanoma cells, and may be enhanced by radiotherapy. The cytokines interferon-alpha and interleukin-2 have been combined with radiotherapy in several small studies, with some evidence suggesting increased toxicity and/or efficacy. Ipilimumab, a monoclonal antibody which blocks cytotoxic T-lymphocyte antigen-4, has been combined with radiotherapy in several notable case studies and series. Finally, pilot studies of adoptive cell transfer have suggested radiotherapy may improve the efficacy of treatment. The review will demonstrate that the combination of radiotherapy and immunotherapy has been reported in several notable case studies, series and clinical trials. These clinical results suggest interaction and the need for further study.