A systematic review of herbal medicinal products for the treatment of menopausal symptoms
A systematic review of herbal medicinal products for the treatment of menopausal symptoms
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DOI：
10.1097/01.gme.0000058147.24036.b0
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发表时间：
2003-09-01
影响因子：
2.7
通讯作者：
Ernst, E
中科院分区：
文献类型：
--
作者：
Huntley, AL;Ernst, E
目的：许多妇女已转向补充和替代药物，以减轻其更年期症状。绝经期妇女中草药产品使用的流行突出了调查这些干预措施的必要性。本研究的目的是评估的好处，草药产品的治疗更年期症状的随机临床试验进行系统的回顾。设计：文献检索的四个计算机数据库进行了识别随机临床试验的草药产品治疗更年期症状。我们联系了草药产品的制造商，也搜索了我们自己的文件。对出版物的语言没有限制。如果结果测量与更年期的生理或心理影响有关，则考虑试验，无论是通过纲要评分，问卷调查还是女性症状日记，不包括描述人工诱导更年期的研究。这篇综述不涉及生化或病理学数据。结果：18项符合我们标准的随机临床试验被确定。这些研究调查了黑升麻（n = 4）、红三叶草（n = 4）、卡瓦（n = 3）、当归（n = 1）、月见报春花油（n = 1）、人参（n = 1）和组合产品（n = 4）。试验质量普遍良好，18项研究中有16项在Jadad Scale.Conclusions评分为3或以上（最高5分），没有令人信服的证据表明任何草药产品在治疗更年期症状。然而，黑升麻的证据是有希望的，尽管受到试验方法的限制。涉及红三叶草的研究表明，它可能对更严重的更年期症状有益。有一些使用卡瓦的证据，但安全问题意味着这种草药产品目前不是一种治疗选择。对于审查的其他草药产品，证据不确定。
Objective: Many women have turned to complementary and alternative medicines for relief from their menopausal symptoms. The prevalence of herbal medicinal product use among menopausal women highlights the need for investigation into these interventions. The aim of this study was to evaluate the benefit of herbal medicinal products for the treatment of menopausal symptoms by performing a systematic review of randomized clinical trials.Design: Literature searches of four computerized databases were done to identify randomized clinical trials of herbal medicinal products for the treatment of menopausal symptoms. Manufacturers of herbal products were contacted, and our own files were also searched. There were no restrictions on the language of publication. Trials were considered if the outcome measures related to the physical or psychological impact of menopause, whether by compendium scores, questionnaires, or women's symptom diaries, excluding studies describing artificially induced menopause. This review was not concerned with biochemical or pathological data.Results: Eighteen randomized clinical trials that fit our criteria were identified. These studies investigated black cohosh (n = 4), red clover (n = 4), kava (n 3), dong qual (n = 1), evening primrose oil (n = 1), ginseng (n = 1), and combination products (n = 4). Trial quality was generally good, with 16 of 18 studies scoring 3 or more (maximum 5) on the Jadad Scale.Conclusions: There is no convincing evidence for any herbal medical product in the treatment of menopausal symptoms. However, the evidence for black cohosh is promising, albeit limited by the poor methodology of the trials. The studies involving red clover suggest it may be of benefit for more severe menopausal symptoms. There is some evidence for the use of kava, but safety concerns mean this herbal product is not a therapeutic option at present. The evidence is inconclusive for the other herbal medicinal products reviewed.