Type-specific regulation of adenylyl cyclase by G protein beta gamma subunits.
Type-specific regulation of adenylyl cyclase by G protein beta gamma subunits.
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DOI：
10.1126/science.1962211
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发表时间：
1991-12
期刊：
影响因子：
56.9
通讯作者：
Wei-Jen Tang;A. Gilman
中科院分区：
文献类型：
--
作者：
Wei-Jen Tang;A. Gilman
异源三聚体鸟嘌呤核苷酸结合调节蛋白(G蛋白)与受体相互作用后，可解离为与三磷酸鸟苷(GTP)结合的α亚基和β、γ亚基的复合体。GTP-α亚单位复合体激活适当的效应器，如腺苷环化酶、视网膜磷酸二酯酶、磷脂酶C和离子通道。已发现G蛋白β-伽马亚基对某些类型的腺酰环化酶有调节作用。在激活腺酰环化酶的G蛋白的α亚基Gsα的存在下，一种形式的腺酰环化酶被β-γ抑制，一些形式被β-γ激活，而一些形式不受β-γ的影响。这些相互作用暗示了不同信号转导通路之间的通信机制。
Heterotrimeric guanine nucleotide-binding regulatory proteins (G proteins) dissociate into guanosine triphosphate (GTP)-bound alpha subunits and a complex of beta and gamma subunits after interaction with receptors. The GTP-alpha subunit complex activates appropriate effectors, such as adenylyl cyclase, retinal phosphodiesterase, phospholipase C, and ion channels. G protein beta gamma subunits have been found to have regulatory effects on certain types of adenylyl cyclase. In the presence of Gs alpha, the alpha subunit of the G protein that activates adenylyl cyclase, one form of adenylyl cyclase was inhibited by beta gamma, some forms were activated by beta gamma, and some forms were not affected by beta gamma. These interactions suggest mechanisms for communication between distinct signal-transducing pathways.