Protein acetylation as a means to regulate protein function in tune with metabolic state
Protein acetylation as a means to regulate protein function in tune with metabolic state
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DOI：
10.1042/bst20140135
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发表时间：
2014-08-01
影响因子：
3.9
通讯作者：
Tu, Benjamin P.
中科院分区：
文献类型：
--
作者：
Shi, Lei;Tu, Benjamin P.
蛋白质乙酰化已经成为一种重要的翻译后修饰，可以发生在各种蛋白质上。代谢物乙酰辅酶A是能量代谢的关键中间体，也是蛋白质乙酰化修饰中的乙酰基供体。因此，这种乙酰化修饰可能与乙酰辅酶A的细胞内可用性相关联。在这篇文章中，我们总结了最近的证据表明，特定的蛋白质乙酰化修饰使蛋白质功能的调节与乙酰辅酶A的可用性，从而细胞的代谢状态。
Protein acetylation has emerged as a prominent post-translational modification that can occur on a wide variety of proteins. The metabolite acetyl-CoA is a key intermediate in energy metabolism that also serves as the acetyl group donor in protein acetylation modifications. Therefore such acetylation modifications might be coupled to the intracellular availability of acetyl-CoA. In the present article, we summarize recent evidence suggesting that the particular protein acetylation modifications enable the regulation of protein function in tune with acetyl-CoA availability and thus the metabolic state of the cell.