Polymorphisms of TGFB1, TLE4 and MUC22 are associated with childhood asthma in Chinese population
Polymorphisms of TGFB1, TLE4 and MUC22 are associated with childhood asthma in Chinese population
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DOI：
10.1016/j.aller.2016.10.021
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发表时间：
2017-09-01
影响因子：
1.8
通讯作者：
Jin, Y. J.
中科院分区：
文献类型：
--
作者：
Chen, J. B.;Zhang, J.;Jin, Y. J.
目的：探讨TGFB1、TLE4、MUC22和IKZF3基因变异是否与中国儿童哮喘的发生有关。方法：本研究纳入572名青少年哮喘患者和590名年龄匹配的健康对照者。总共对4个SNP进行了基因分型，包括TGFB1的rs2241715、TLE4的rs2378383、MUC22的rs2523924和IKZF3的rs907092。通过卡方检验比较患者和对照组的等位基因频率。采用Student t检验分析患者基因型与临床特征之间的关系。结果：与对照组相比，患者的rs2241715等位基因A、rs2378383等位基因G和rs2523924等位基因A频率显着差异（40.4% vs. 45.9%，rs2241715 p = 0.01； rs2378383 为 17.2% 与 13.4%，p= 0.01；rs2523924 为 15.3% 与 11.9%，p= 0.02）。对于重度哮喘患者，rs2241715基因型AA/AG患者的FEV1%显着高于基因型GG患者（59.1 +/- 4.3% vs. 55.4 +/- 3.7%，p < 0.001）。此外，rs2378383基因型GG/GA患者的FEV1%显着低于AA基因型患者（54.6 +/- 2.9% vs. 58.6 +/- 4.1%，p < 0.001）。结论：TGFB1、TLE4和MUC22基因与中国人群儿童哮喘风险相关。我们将 TGFB1 和 TLE4 与哮喘临床特征联系起来的结果表明这些参数在哮喘儿童管理中的潜在应用。 (C) 2017 年 SEICAP。由 Elsevier Espana, S.L.U. 出版版权所有。
Objective: To investigate whether the genetic variants of TGFB1, TLE4, MUC22 and IKZF3 are associated with the development of asthma in Chinese children.Methods: 572 adolescent asthma patients and 590 age -matched healthy controls were included in this study. A total of four SNPs were genotyped, including rs2241715 of TGFB1, rs2378383 of TLE4, rs2523924 of MUC22, and rs907092 of IKZF3. Allele frequencies of the patients and the control group were compared by the Chi-square test. The Student t test was used to analyse the relationship between genotypes and clinical feature of the patients.Results: Patients were found to have significantly different frequencies of allele A of rs2241715, allele G of rs2378383 and allele A of rs2523924 as compared with the controls (40.4% vs. 45.9%, p = 0.01 for rs2241715; 17.2% vs. 13.4%, p= 0.01 for rs2378383; 15.3% vs. 11.9%, p= 0.02 for rs2523924). For patients with severe asthma, those with genotype AA/AG of rs2241715 had remarkably higher FEV1% as compared with those with genotype GG (59.1 +/- 4.3% vs. 55.4 +/- 3.7%, p < 0.001). Moreover, those with genotype GG/GA of rs2378383 had remarkably lower FEV1% as compared with those with genotype AA (54.6 +/- 2.9% vs. 58.6 +/- 4.1%, p < 0.001).Conclusions: Genes TGFB1, TLE4 and MUC22 are associated with the risk of childhood asthma in Chinese population. Our results associating TGFB1 and TLE4 with clinical features of asthma suggest potential application of these parameters in the management of asthma children. (C) 2017 SEICAP. Published by Elsevier Espana, S.L.U. All rights reserved.