Hyperthermia-related clinical trials on cancer treatment within the ClinicalTrials.gov registry
Hyperthermia-related clinical trials on cancer treatment within the ClinicalTrials.gov registry
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DOI：
10.3109/02656736.2015.1040471
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发表时间：
2015-01-01
影响因子：
3.1
通讯作者：
Ghadjar, Pirus
中科院分区：
文献类型：
--
作者：
Cihoric, Nikola;Tsikkinis, Alexandros;Ghadjar, Pirus
目的：热疗已被证明可以提高化疗和放疗治疗癌症的有效性。本文总结了最近在ClinicalTrials.gov注册中心注册的所有临床试验。材料与方法：于2014年9月29日下载ClinicalTrials.gov网站注册的175,538项临床试验记录，并建立数据库。我们在这个数据库中搜索了热疗或类似的词汇。结果：共有109项试验确定热疗是治疗方案的一部分。其中，49项试验（45%）将细胞减少手术（HIPEC）后的腹腔热化疗作为主要干预措施，另外14项试验（13%）也测试了某种形式的腹腔热化疗灌流。7项试验（6%）测试了其他部位的灌注尝试（胸/胸膜n = 4，肢体n = 2，肝脏n = 1）。16项试验（15%）为局部热疗，13项试验（12%）为全身热疗，7项试验（6%）为浅表热疗，2项试验（2%）为间质热疗。剩下的一项试验是激光热疗。结论：与一般观点相反，该分析显示了热疗领域持续的兴趣和正在进行的临床研究。有趣的是，大多数试验集中于某种形式的腹腔热灌注。尽管有大量活跃的临床研究，HIPEC在欧洲热疗肿瘤学会和热疗医学学会的年会上是一个关注有限的话题。正在进行的临床试验的注册对于实现对涉及热疗的可用临床研究活动的全面概述至关重要。
Purpose: Hyperthermia has been shown to improve the effectiveness of chemotherapy and radiotherapy in the treatment of cancer. This paper summarises all recent clinical trials registered in the ClinicalTrials.gov registry. Materials and methods: The records of 175,538 clinical trials registered at ClinicalTrials.gov were downloaded on 29 September 2014 and a database was established. We searched this database for hyperthermia or equivalent words. Results: A total of 109 trials were identified in which hyperthermia was part of the treatment regimen. Of these, 49 trials (45%) had hyperthermic intraperitoneal chemotherapy after cytoreductive surgery (HIPEC) as the primary intervention, and 14 other trials (13%) were also testing some form of intraperitoneal hyperthermic chemoperfusion. Seven trials (6%) were testing perfusion attempts to other locations (thoracic/pleural n = 4, limb n = 2, hepatic n = 1). Sixteen trials (15%) were testing regional hyperthermia, 13 trials (12%) whole body hyperthermia, seven trials (6%) superficial hyperthermia and two trials (2%) interstitial hyperthermia. One remaining trial tested laser hyperthermia. Conclusions: In contrast to the general opinion, this analysis shows continuous interest and ongoing clinical research in the field of hyperthermia. Interestingly, the majority of trials focused on some form of intraperitoneal hyperthermic chemoperfusion. Despite the high number of active clinical studies, HIPEC is a topic with limited attention at the annual meetings of the European Society for Hyperthermic Oncology and the Society of Thermal Medicine. The registration of on-going clinical trials is of paramount importance for the achievement of a comprehensive overview of available clinical research activities involving hyperthermia.