Glycolipids in Histologically Human Different Lung Carcinoma Types
Glycolipids in Histologically Human Different Lung Carcinoma Types
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组织学上人类不同肺癌类型中的糖脂
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
M. Hashimoto
中科院分区：
文献类型：
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作者：
Y. Yoda;S. Gasa;A. Makita;Y. Fujioka;Y. Kikuchi;M. Hashimoto
从不同组织类型的原发人类肺癌组织中分离出糖脂：腺癌、鳞状细胞癌和未分化小细胞癌。每种类型的癌都有其特有的糖脂模式。分离得到的糖脂主要为神经酰胺单己糖苷、神经酰胺二己糖苷、神经酰胺三己糖苷、球状糖苷和血糖苷。鳞状细胞癌和未分化小细胞癌中神经酰胺单己糖苷和二己糖苷含量明显增加。与鳞状细胞癌、未分化小细胞癌或正常肺组织相比，腺癌中硫脂(神经酰胺-3-硫酸酯-半乳糖苷)的水平要高得多。与其他癌症相比，胚胎组织中硫脂的水平更高。腺癌患者的糖脂水平显著降低，主要原因是神经酰胺、单己糖苷、二己糖苷和血糖苷的含量减少。
Glycolipids were isolated from primary human lung carcinoma tissue of various histologic types: adenocarcinoma, squamous cell carcinoma, and undifferentiated small cell carcinoma. Each type of carcinoma had a characteristic glycolipid pattern. The major glycolipids isolated were ceramide monohexosides, ceramide dihexosides, ceramide trihexosides, globoside, and hematoside. Squamous cell carcinoma and undifferentiated small cell carcinoma showed marked increases of ceramide monohexosides and dihexosides. Adenocarcinoma had a much higher level of the sulfatide (ceramide 3-sulfate-galactoside) as compared to squamous cell carcinoma, undifferentiated small cell carcinoma, or normal lung tissue. Embryonic tissue had more significant levels of sulfatide than did the other carcinomas. Adenocarcinoma had significantly lower levels of glycolipids due mainly to a decrease in the amount of ceramide monohexosides and dihexosides and hematoside.