Measurement of brain glutamate using TE-averaged PRESS at 3T
Measurement of brain glutamate using TE-averaged PRESS at 3T
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DOI：
10.1002/mrm.20007
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发表时间：
2004-03-01
影响因子：
3.3
通讯作者：
Nelson, SJ
中科院分区：
文献类型：
--
作者：
Hurd, R;Sailasuta, N;Nelson, SJ
介绍了一种改进的谷氨酸（Glu）、谷氨酰胺（Gln）、胆碱（Cho）、肌酸（Cre）、N-乙酰化合物（NA（tot）、NAA + NAAG）和肌醇（ml和sl）的体内光谱测量方法。发现在3 T下，TE平均，2D J分辨光谱的f1 = 0切片，产生Glu、Glu + Gln（Glx）、ml、NA（tot）、Cre和Cho的无障碍信号。Glu在2.35 ppm处的C4质子和Glx在3.75 ppm处的C2质子被很好地分辨，并产生Glu/Gln停滞的可靠测量。从原始数据中获得表观T-1/T-2值，并相对于现成标准品测定代谢物组织水平。重复性误差为
A method is introduced that provides improved in vivo spectroscopic measurements of glutamate (Glu), glutamine (Gin), choline (Cho), creatine (Cre), N-acetyl compounds (NA(tot), NAA + NAAG), and the inositols (ml and sl). It was found that at 3T, TE averaging, the f1 = 0 slice of a 2D J-resolved spectrum, yielded unobstructed signals for Glu, Glu + Gin (Glx), ml, NA(tot), Cre, and Cho. The C4 protons of Glu at 2.35 ppm, and the C2 protons of Glx at 3.75 ppm were well resolved and yielded reliable measures of Glu/Gln stasis. Apparent T-1/T-2 values were obtained from the raw data, and metabolite tissue levels were determined relative to a readily available standard. A repeatibility error of