PHARMACOLOGICAL INDUCTION OF USE-DEPENDENT RECEPTIVE-FIELD MODIFICATIONS IN THE VISUAL-CORTEX
PHARMACOLOGICAL INDUCTION OF USE-DEPENDENT RECEPTIVE-FIELD MODIFICATIONS IN THE VISUAL-CORTEX
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DOI：
10.1126/science.2902687
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发表时间：
1988-10-07
期刊：
影响因子：
56.9
通讯作者：
SINGER, W
中科院分区：
文献类型：
--
作者：
GREUEL, JM;LUHMANN, HJ;SINGER, W
视觉刺激与神经调节剂乙酰胆碱和去甲肾上腺素或兴奋性氨基酸N-甲基-D-天冬氨酸和L-谷氨酸的离子导入相结合，可以诱导视觉皮质神经元感受野的持久改变。修改在不到1小时内获得，持续时间超过40分钟。因此，乙酰胆碱和去甲肾上腺素在使用依赖性神经元可塑性中具有允许的作用。这些结果支持神经元延展性的突触后阈值不同于钠依赖动作电位的概念。
Lasting modifications of the receptive fields of neurons in the visual cortex can be induced by pairing visual stimuli with iontophoretic application of the neuromodulators acetylcholine and noradrenaline or the excitatory amino acids N-methyl-D-aspartate (NMDA) and L-glutamate. The modifications are obtained in less than 1 hour and persist for more than 40 minutes. Thus, acetylcholine and norepinephrine have permisive role in use-dependent neuronal plasticity. These results support the notion of a postsynaptic threshold for neuronal malleability that differs from that of sodium-dependent action potentials.