The resistance of breast cancer stem cells to conventional hyperthermia and their sensitivity to nanoparticle-mediated photothermal therapy.
The resistance of breast cancer stem cells to conventional hyperthermia and their sensitivity to nanoparticle-mediated photothermal therapy.
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DOI：
10.1016/j.biomaterials.2011.12.052
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发表时间：
2012-04
期刊：
影响因子：
14
通讯作者：
Torti, Suzy V.
中科院分区：
文献类型：
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作者：
Burke, Andrew R.;Singh, Ravi N.;Carroll, David L.;Wood, James C. S.;D'Agostino, Ralph B., Jr.;Ajayan, Pulickel M.;Torti, Frank M.;Torti, Suzy V.
乳腺肿瘤含有少量肿瘤起始干细胞样细胞，称为乳腺癌干细胞（BCSC）。这些对化疗和放疗难治的细胞被认为在治疗后持续存在并驱动肿瘤复发。我们研究了BCSCs是否对热疗具有类似的抵抗力，以及纳米颗粒是否可以用来克服这种抵抗力。使用三阴性乳腺癌干细胞的模型，我们表明BCSC对传统的热疗有显著的抵抗力，并且在治疗后存活的细胞群中富集。相比之下，BCSCs对纳米管介导的热治疗敏感，并且在纳米管介导的热治疗后失去其长期增殖能力。此外，在体内使用这种疗法促进了肿瘤完全消退和携带癌症干细胞驱动的乳腺肿瘤的小鼠的长期存活。从机制上讲，纳米管热疗法促进BCSC的快速膜透化和坏死。这些数据表明，纳米管介导的热处理可以同时消除构成肿瘤主体的分化细胞和驱动肿瘤生长和复发的BCSC。
Breast tumors contain a small population of tumor initiating stem-like cells, termed breast cancer stem cells (BCSCs). These cells, which are refractory to chemotherapy and radiotherapy, are thought to persist following treatment and drive tumor recurrence. We examined whether BCSCs are similarly resistant to hyperthermic therapy, and whether nanoparticles could be used to overcome this resistance. Using a model of triple-negative breast cancer stem cells, we show that BCSCs are markedly resistant to traditional hyperthermia and become enriched in the surviving cell population following treatment. In contrast, BCSCs are sensitive to nanotube-mediated thermal treatment and lose their long-term proliferative capacity after nanotube-mediated thermal therapy. Moreover, use of this therapy in vivo promotes complete tumor regression and long-term survival of mice bearing cancer stem cell-driven breast tumors. Mechanistically, nanotube thermal therapy promotes rapid membrane permeabilization and necrosis of BCSCs. These data suggest that nanotube-mediated thermal treatment can simultaneously eliminate both the differentiated cells that constitute the bulk of a tumor and the BCSCs that drive tumor growth and recurrence.
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影响因子：
10.5
作者：
Dontu, G;Abdallah, WM;Wicha, MS
通讯作者：
Wicha, MS
影响因子：
11.2
作者：
Charafe-Jauffret E;Ginestier C;Iovino F;Wicinski J;Cervera N;Finetti P;Hur MH;Diebel ME;Monville F;Dutcher J;Brown M;Viens P;Xerri L;Bertucci F;Stassi G;Dontu G;Birnbaum D;Wicha MS
通讯作者：
Wicha MS
DOI：
10.1073/pnas.2232479100
发表时间：
2003-11-11
影响因子：
11.1
作者：
Hirsch, LR;Stafford, RJ;West, JL
通讯作者：
West, JL
影响因子：
12.4
作者：
Eramo, A.;Lotti, F.;De Maria, R.
通讯作者：
De Maria, R.
影响因子：
38.3
作者：
通讯作者：
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