GESTATIONAL DIABETES IN THE BHE RAT - INFLUENCE OF DIETARY-FAT
GESTATIONAL DIABETES IN THE BHE RAT - INFLUENCE OF DIETARY-FAT
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DOI：
10.1016/0002-9378(89)90272-x
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发表时间：
1989-07-01
影响因子：
9.8
通讯作者：
BERDANIER, CD
中科院分区：
文献类型：
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作者：
BUE, JM;HAUSMAN, DB;BERDANIER, CD
进行了两项研究来评估脂肪喂养对 BHE 大鼠妊娠前、妊娠期间和妊娠后葡萄糖耐量的影响。在第一项研究中，从交配前 3 周到妊娠后饲喂 5% 或 22% 的脂肪饮食。在第二项研究中，从断奶到 400 日龄期间均饲喂这些日粮。在短期研究中，妊娠前后的葡萄糖耐量不受饮食的影响。妊娠19天时，喂食22%脂肪饮食的怀孕大鼠的葡萄糖耐量恶化。在长期研究中，喂食 22% 脂肪饮食的老鼠在交配前观察到葡萄糖耐量异常。妊娠期和产后耐受性有所改善，但仍不正常。喂食 22% 脂肪饮食的大鼠的生育能力和幼仔存活率显着降低 (50%)。这些发现表明，短期或长期喂养 BHE 数据的 22% 脂肪饮食会产生人类妊娠糖尿病模型，该模型可能值得进一步研究。
Two studies were performed to assess the effects of fat feeding on glucose tolerance before, during, and after gestation of BHE rats. In the first study 5% or 22% fat diets were fed from 3 weeks before mating until after gestation. In the second study, these diets were fed from weaning until 400 days of age. Glucose tolerance before and after gestation was not affected by diet in the short-term study. At 19 days'' gestation, glucose tolerance had deterioraed in the pregnant rats that were fed with 22% fat diet. In the long-term study, abnormal glucose tolerance was observed before mating in rats that were fed the 22% fat diet. Tolerance improved during gestation and post partum, but still was not normal. Fertility and pup survival were significantly (50%) reduced in rats that were fed the 22% fat diet. These findings suggest that either short-term or long-term feeding of a 22% fat diet to BHE dats results in a model for human gestational diabetes that might be worthy of further study.