Canine lymphoma as a comparative model for human non-Hodgkin lymphoma: recent progress and applications.
Canine lymphoma as a comparative model for human non-Hodgkin lymphoma: recent progress and applications.
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DOI：
10.1016/j.vetimm.2014.02.016
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发表时间：
2014-06-15
影响因子：
1.8
通讯作者：
Modiano JF
中科院分区：
文献类型：
--
作者：
Ito D;Frantz AM;Modiano JF
术语“淋巴瘤”描述了涉及恶性淋巴细胞的单克隆增殖的一组异质性疾病。作为一个群体，淋巴瘤是狗最常见的肿瘤之一。然而，我们对淋巴瘤的许多亚型的枚举和理解相对缓慢，部分原因可能是多年来淋巴瘤被视为一个单一的实体，而不是一组不同的疾病。认识到在人类中观察到的全谱淋巴恶性肿瘤也发生在狗中，并且这些肿瘤不仅保留了形态学相似性和生物学行为，而且还保留了同义驱动分子异常，这为双重目的的研究奠定了理想的基础，可以加速这两个物种中这些疾病的进展。具体来说，狗代表了在相对较短的时间内定义因果关系，理解进展和开发淋巴瘤新疗法的特殊模型。犬模型的独特优势包括：（1）自发性疾病发生，没有同基因背景或基因工程;（2）适应寿命的疾病年表;（3）共享环境和社会地位，允许将犬视为“患者”，同时能够在伦理上探索人类受试者不可能的转化创新;和（4）组织狗品种相对同质的遗传背景和不同的倾向，淋巴瘤。在这里，我们将回顾最近的研究，描述内在和外在因素，有助于犬和人类淋巴瘤的发病机制，以及新开发的工具，将提高这些模型的保真度，以改善诊断和开发新的治疗方法。
The term “lymphoma” describes a heterogeneous group of disorders involving monoclonal proliferation of malignant lymphocytes. As a group, lymphomas are among the most common tumors of dogs. Yet our enumeration and understanding of the many subtypes of lymphoma have been relatively slow, perhaps in part because for many years lymphoma was treated as a singular entity rather than a group of distinct diseases. The recognition that the full spectrum of lymphoid malignancies seen in humans also occurs in dogs, and that these tumors retain not only morphologic similarities and biological behavior but also synonymous driver molecular abnormalities, sets an ideal stage for dual-purpose research that can accelerate progress for these diseases in both species. Specifically, dogs represent exceptional models for defining causality, understanding progression, and developing new treatments for lymphoma in comparatively brief windows of time. Unique advantages of canine models include (1) spontaneous disease occurring without an isogenic background or genetic engineering; (2) chronology of disease adapted to lifespan, (3) shared environment and societal status that allows dogs to be treated as “patients,” while at the same time being able to ethically explore translational innovations that are not possible in human subjects; and (4) organization of dogs into breeds with relatively homogeneous genetic backgrounds and distinct predisposition for lymphomas. Here, we will review recent studies describing intrinsic and extrinsic factors that contribute to the pathogenesis of canine and human lymphomas, as well as newly developed tools that will enhance the fidelity of these models to improve diagnosis and develop new treatments.